PMID: 11770059Jan 5, 2002Paper

Adenosine A1 receptor activation selectively impairs the acquisition of contextual fear conditioning in rats

Behavioral Neuroscience
K P Corodimas, H Tomita

Abstract

Three experiments were conducted to examine the importance of adenosine A1 receptors for the acquisition and expression of hippocampal-dependent and hippocampal-independent forms of conditioned fear. In Experiment 1, the selective adenosine A1 receptor agonist, N6-cyclopentyladenosine (CPA), or saline was administered intraperitoneally to male rats 30 min prior to Pavlovian fear conditioning, which consisted of 7 tone-shock pairings. Adenosine A1 receptor activation dose-dependently and selectively disrupted the acquisition of contextual fear conditioning while sparing tone-shock associations. Experiments 2 and 3 demonstrated that CPA's selective disruption of contextual learning could not be attributed to context being weaker than tone conditioning or to state-dependent learning. Adenosine A1 receptor activation also impaired the expression of both context- and tone-elicited fear. These results suggest that endogenous adenosine modulates the acquisition and expression of emotional (fear) memories by acting on A1 receptors in brain regions underlying fear conditioning.

References

May 28, 1979·Life Sciences·M L MichaelisS L Myers
Sep 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·D A Prince, C F Stevens
Jan 1, 1992·Annual Review of Neuroscience·M Davis
May 1, 1992·Science·J J Kim, M S Fanselow
Jan 1, 1992·Archives of Orthopaedic and Trauma Surgery·K SteffensG Hong
Aug 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·S FerreK Fuxe
Oct 30, 1990·Neuroscience Letters·A AraiG Lynch
May 3, 1990·European Journal of Pharmacology·T Zetterström, M Fillenz
Sep 1, 1985·Acta Physiologica Scandinavica·J Fastbom, B B Fredholm
Jan 2, 1985·European Journal of Pharmacology·T J FeuersteinR Jackisch
Jan 1, 1967·Psychological Review·R A Rescorla
Apr 1, 1970·Journal of Comparative and Physiological Psychology·R J BlanchardR A Fial
Aug 1, 1968·Journal of Comparative and Physiological Psychology·R A Rescorla
Sep 3, 1984·European Journal of Pharmacology·R CorradettiG Pepeu
Jan 27, 1984·European Journal of Pharmacology·G SpignoliG Pepeu
Jan 1, 1995·Annual Review of Psychology·J E LeDoux
Sep 1, 1994·Behavioral and Neural Biology·H J NormileR A Barraco
May 2, 1994·European Journal of Pharmacology·M R Zarrindast, B Shafaghi
Jan 1, 1993·Brain Research Bulletin·R A BarracoH J Normile
Apr 1, 1996·Current Opinion in Neurobiology·T W Robbins, B J Everitt
Feb 1, 1996·Neuron·S Maren, M S Fanselow
Dec 25, 1995·The Journal of Comparative Neurology·T H SwansonS A Rivkees
May 23, 1997·Science·T Porkka-HeiskanenR W McCarley
Mar 12, 1999·Neuroscience and Biobehavioral Reviews·A Nehlig
May 3, 2000·Neuroreport·S A RivkeesH Hao

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Citations

Jun 23, 2011·Purinergic Signalling·Ahmed-Ramadan SadekGeoffrey Burnstock
Apr 12, 2005·Neurobiology of Learning and Memory·Grace Schenatto PereiraIván Izquierdo
Apr 29, 2004·Behavioral Neuroscience·Stephanie Moriceau, Regina M Sullivan
Sep 3, 2013·Journal of Psychiatric Research·Edward F Pace-SchottMohammed R Milad
Feb 24, 2018·Frontiers in Aging Neuroscience·Soghra BagheriAli A Saboury
Jul 2, 2008·Nature Reviews. Drug Discovery·Geoffrey Burnstock
Apr 13, 2007·Physiological Reviews·Geoffrey Burnstock
Dec 18, 2013·Pharmacological Reviews·Suzanne WoodStephan G Anagnostaras

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