Adenosine A(1) receptor antagonist and mitochondrial ATP-sensitive potassium channel blocker attenuate the tolerance to focal cerebral ischemia in rats

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Mitsuyoshi YoshidaTakefumi Sakabe

Abstract

Involvement of adenosine and adenosine triphosphate-sensitive potassium (KATP) channels in the development of ischemic tolerance has been suggested in global ischemia, but has not been studied extensively in focal cerebral ischemia. This study evaluated modulating effects of adenosine A1 receptor antagonist DPCPX (8-cyclopentyl-1,3-dipropylxanthine) and mitochondrial KATP channel blocker 5HD (5-hydroxydecanoate) on the development of tolerance to focal cerebral ischemia in rats. Preconditioning with 30-minute middle cerebral artery occlusion (MCAO) reduced cortical and subcortical infarct volume following 120-minute MCAO (test ischemia) given 72 hours later. The neuroprotective effect of preconditioning was attenuated by 0.1 mg/kg DPCPX given before conditioning ischemia (30-minute MCAO), but no influence was provoked when it was administered before test ischemia. DPCPX had no effect on infarct volume after conditioning or test ischemia when given alone. The preconditioning-induced neuroprotection disappeared when 30 mg/kg 5HD was administered before test ischemia. These results suggest a possible involvement of adenosine A1 receptors during conditioning ischemia and of mitochondrial KATP channels during subsequent severe ische...Continue Reading

References

Apr 1, 1992·Stroke; a Journal of Cerebral Circulation·H MemezawaB K Siesjö
Mar 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R A SwansonF R Sharp
Sep 24, 1990·Brain Research·K KitagawaK Mikoshiba
May 9, 1995·Proceedings of the National Academy of Sciences of the United States of America·C HeurteauxM Lazdunski
Dec 1, 1996·Neuroscience·M A Pérez-PinzónT J Sick
Jul 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J ChenR P Simon
May 20, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·N KawaharaT Kirino
Jun 4, 1999·European Journal of Pharmacology·D K von Lubitz
Dec 22, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·H PlamondonM Lazdunski
Jun 14, 2000·Neurology·J MoncayoG van Melle
Nov 14, 2000·Circulation Research·B O'Rourke
Nov 25, 2000·Circulation Research·R Bolli
Apr 11, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S ShimizuR P Simon
Jan 16, 2002·The Annals of Thoracic Surgery·J G ShakeW A Baumgartner
Feb 2, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Michiko NakamuraTakefumi Sakabe
Mar 29, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Dong LiuMark P Mattson
Jun 11, 2002·American Journal of Physiology. Cell Physiology·Lobelia SamavatiGary W Hunninghake
Aug 3, 2002·The Journal of Physiology·Peter J HanleyJürgen Daut
Aug 6, 2002·Cardiovascular Research·G F Baxter
Aug 16, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Katsuyoshi ShimizuDavid W Busija
Nov 20, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Takaaki Kirino
May 15, 2003·Trends in Neurosciences·Ulrich DirnaglJohn M Hallenbeck
Sep 13, 2003·European Journal of Pharmacology·John W Phillis, Michael H O'Regan

❮ Previous
Next ❯

Citations

Jan 26, 2006·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Yanhong LiuQiang Wang
May 23, 2006·Nature Reviews. Neuroscience·Jeffrey M Gidday
Jan 2, 2007·Anesthesiology·Hiroaki SakaiDavid S Warner
Mar 20, 2010·Experimental & Translational Stroke Medicine·Aysan Durukan, Turgut Tatlisumak
Jun 22, 2010·Translational Stroke Research·Richard F KeepGuohua Xi
Aug 21, 2013·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Lei ZhangShilei Wang
Jul 1, 2008·Neuroscience Letters·Rachel BrightDaria Mochly-Rosen
Sep 9, 2008·Brain Research·Megumi WatanabeYasuo Katayama
Oct 20, 2006·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Sarah L Milton, Howard M Prentice
Nov 20, 2015·Neuropharmacology·Felicita PedataAnna Maria Pugliese
Apr 20, 2006·Respiratory Physiology & Neurobiology·L T Buck, M E Pamenter
Jun 16, 2015·Frontiers in Neurology·Maria Josè SisalliAntonella Scorziello
Apr 2, 2013·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Huanli DongZhong Liu
Dec 15, 2010·Biochimica Et Biophysica Acta·Catarina V GomesRodrigo A Cunha
Sep 14, 2014·British Journal of Anaesthesia·C K Pac-SooD Ma
Jul 2, 2016·Journal of Neurochemistry·Rodrigo A Cunha
Sep 7, 2016·Scandinavian Cardiovascular Journal : SCJ·Vesa AnttilaTatu Juvonen
Sep 29, 2017·Neurologia Medico-chirurgica·Masatoshi YunokiKimihiro Yoshino
Apr 7, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Chih-Sen KangTsung-Ming Lee
Jul 15, 2006·The Journal of Pharmacology and Experimental Therapeutics·Dong-Mei ChenXing-Zu Zhu
Sep 25, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Tsung-Ming LeeNen-Chung Chang
May 9, 2015·Journal of Applied Physiology·Robert Meller, Roger P Simon
Oct 22, 2008·The Journal of Experimental Biology·Matthew E Pamenter, Leslie T Buck

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.