Abstract
Orthosiphon stamineus Benth. ( Orthosiphon Grandiflorus Bold. or Clerodendranthus spicatus Thunb.) is an Indonesian medicinal herb traditionally used for diseases such as hypertension, diabetes, and kidney stones. Despite the importance of this last application, there are very few reports on it. Diuretic action is an important factor in kidney stone treatment, as an increase in the volume of fluid flowing through the kidney will help to dissolve the stones, assist their passing to avoid further retention, and flush out the deposits. Among the diverse roles of adenosine A (1) receptor antagonists in renal protection, many studies have shown that they can induce diuresis and sodium excretion. A bioassay-guided fractionation of a methanol-water extract of Orthosiphon stamineus leaves using the adenosine A (1) receptor binding assay resulted in the isolation of seven methoxy flavonoids as active ligands with K(i) values in the micromolar range. The Hill slope values are not significantly different from unity (within 0.9 - 1.4), which indicates the antagonist effect to A (1)-R. The results of this study thus provide a scientific foundation for the traditional use ofOrthosiphon stamineus in kidney stone treatment, as the affinity of ...Continue Reading
Citations
Nov 12, 2010·Urological Research·P VanachayangkulVeronika Butterweck
Aug 1, 2012·Journal of Medicinal Food·Omar Z AmeerMun Fei Yam
May 18, 2013·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Samineh JafariMahnaz Khanavi
Jun 21, 2014·Journal of Ayurveda and Integrative Medicine·Poonam VermaAjudhia N Kalia
Nov 21, 2014·Journal of Clinical Biochemistry and Nutrition·Zhongjiang PengZhiyong Guo
Nov 19, 2010·Kidney International·Hyo-Jung LeeSung-Hoon Kim
Aug 29, 2013·Journal of Ethnopharmacology·Nancy Dewi YulianaYoung Hae Choi
Jun 15, 2011·Food Chemistry·Nancy Dewi YulianaRobert Verpoorte
Jan 15, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Siddig Ibrahim AbdelwahabKhalid M Alkharfy
Dec 10, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Annie GeorgeHoi Jin Wong
Aug 2, 2011·Analytical Chemistry·Nancy Dewi YulianaYoung Hae Choi
Feb 16, 2017·Pharmaceutical Biology·Mariem ChaâbaneNajiba Zeghal
Feb 25, 2017·Journal of the Science of Food and Agriculture·Raghunath PariyaniKhozirah Shaari
Oct 11, 2015·BioFactors·Ching-Shu LaiMin-Hsiung Pan
Jan 26, 2010·Journal of Cardiovascular Pharmacology and Therapeutics·Maria Rosaria CesaroneLuciano Pellegrini
Feb 8, 2018·Chemistry & Biodiversity·Nada M MostafaOmayma A Eldahshan
Aug 24, 2018·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Manel GargouriAbdelfattah El Feki
Oct 31, 2017·Asian Pacific Journal of Tropical Medicine·Meryem BakourBadiaa Lyoussi
Sep 11, 2019·Applied Microbiology and Biotechnology·Shabnam Sarshar BeydokhtiAndreas Hensel
Apr 20, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Nurul Huda Mohd NorHadijah Hassan
Jul 26, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Luya LiLantong Zhang
Dec 10, 2020·Journal of Pharmaceutical and Biomedical Analysis·Osama A El-SabaghEngy A Mahrous
Jan 26, 2021·Environmental Science and Pollution Research International·May N Bin-JumahMohamed M Abdel-Daim
Dec 31, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Gebrelibanos Gebremichael WeluMehari Meles Lema
Feb 26, 2021·Frontiers in Pharmacology·Lee Han JieKhairana Husain
Jun 28, 2021·Molecular Diversity·Chrisna MattheeHelena D Janse van Rensburg