PMID: 8945765Nov 8, 1996Paper

Adenosine A1 receptor blockade selectively potentiates the motor effects induced by dopamine D1 receptor stimulation in rodents

Neuroscience Letters
P PopoliS Ferré

Abstract

An antagonistic interaction between adenosine A1 and dopamine D1 receptors has previously been found in the basal ganglia. However, direct evidence for a selective adenosine A1 antagonist-induced potentiation of dopamine D1-mediated motor activation is lacking. The systemic administration of the adenosine A1 antagonist 8-cyclopentyl-1,3-dimethylxanthine significantly potentiated the motor activating properties of the systemically administered dopamine D1 agonist SKF 38393 in both reserpinized mice and unilaterally 6-hydroxy-dopamine-lesioned rats. However, 8-cyclopentyl-1, 3-dimethylxanthine did not modify the motor effects of the dopamine D2 agonist quinpirole. The present work shows that an antagonistic interaction between adenosine A1 and dopamine D1 receptors may be involved in the motor activating effects of adenosine antagonists, like caffeine.

References

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Aug 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·S FerreK Fuxe
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Citations

May 11, 2005·Experimental Brain Research·Branka JanaćMirjana Stojiljković
Mar 10, 2004·Pharmacology, Biochemistry, and Behavior·Branka JanaćLjubisa Rakić
Dec 6, 2001·European Journal of Pharmacology·O P Dall'IgnaD R Lara
Aug 26, 1998·Drug and Alcohol Dependence·J W Daly, B B Fredholm
May 2, 2001·Parkinsonism & Related Disorders·S FerréK Fuxe
Mar 16, 2005·Behavioural Pharmacology·O Cauli, M Morelli
Dec 9, 2014·Expert Opinion on Therapeutic Targets·Kjell FuxeDasiel O Borroto-Escuela
Feb 14, 2015·Expert Opinion on Drug Safety·Thomas Müller
Jul 16, 2009·Pharmacology, Biochemistry, and Behavior·J TrevittC Larsen
Dec 20, 2007·Journal of Neurochemistry·Sergi Ferré
Mar 30, 2010·CNS Neuroscience & Therapeutics·K FuxeL F Agnati
Jan 8, 2013·Pharmacology, Biochemistry, and Behavior·Philipp SingerBenjamin K Yee
Feb 15, 2011·Biochimica Et Biophysica Acta·Francisco CiruelaVíctor Fernández-Dueñas
Feb 15, 2011·Neuropharmacology·Detlev BoisonBenjamin K Yee
Aug 2, 2005·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Alexander KuzminBertil B Fredholm
Sep 12, 2009·Atencion primaria·Rafael Franco
Jul 17, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Omar CauliMicaela Morelli
Sep 29, 2017·Journal of Neurophysiology·David Acton, Gareth B Miles
May 26, 2018·Molecular Neurobiology·Marla Rivera-OliverManuel Díaz-Ríos
Nov 5, 1998·The Journal of Comparative Neurology·H J Bennett, K Semba

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