Abstract
The voltage-gated Ca(2+) channels responsible for synaptic transmission at CA3-CA1 synapses are mainly P/Q- and N-types. It has been shown that tonic inhibition of transmission due to activation of adenosine A(1) receptors occurs at this synapse. We have recently developed a technique to monitor synaptically released glutamate which is based on synaptically induced glial depolarisation. Using this technique, we have examined the effects of different voltage-gated Ca(2+) channel blockers on glutamate release. Under conditions in which the adenosine A(1) receptor was not blocked, omega-AgaIVA (a P/Q-type voltage-gated Ca(2+) channel blocker) suppressed synaptically induced glial depolarisation to a greater extent than omega-CgTxGVIA (an N-type voltage-gated Ca(2+) channel blocker) did. In contrast, in the presence of an adenosine A(1) receptor antagonist, omega-AgaIVA was less effective at suppressing synaptically induced glial depolarisation than omega-CgTxGVIA. These results indicate that, in the absence of adenosine A(1) receptor-mediated tonic inhibition, the contribution of N-type is much greater than that of P-type, and that N-types are the primary target of tonic inhibition in normal conditions in which adenosine A(1) rece...Continue Reading
References
Oct 1, 1985·The Journal of Physiology·G J AugustineS J Smith
Jul 28, 1995·Journal of Molecular Biology·J I KimY Arata
Apr 1, 1995·Neuron·H Reuter
Apr 1, 1994·Science·D B WheelerR W Tsien
Nov 11, 1993·Nature·T Takahashi, A Momiyama
Nov 1, 1993·Neuron·J I LuebkeT J Turner
May 1, 1994·Neuron·L G Wu, P Saggau
Feb 1, 1993·Neuron·D J MogulA P Fox
Sep 16, 1993·Nature·H Yawo, N Chuhma
Jul 1, 1995·Progress in Neurobiology·U MisgeldW Jarolimek
Jun 1, 1996·Current Opinion in Neurobiology·H Reuter
May 1, 1997·Trends in Neurosciences·L G Wu, P Saggau
Apr 16, 1998·European Journal of Pharmacology·A F AmbrósioC M Carvalho
Feb 12, 1999·Brain Research. Brain Research Reviews·R Anwyl
Sep 3, 1999·Neuroscience·T OchiishiY Sekino
Nov 11, 1999·The Journal of Membrane Biology·Y Momose-SatoK Kamino
Aug 11, 2000·Journal of Neurochemistry·J Cartmell, D D Schoepp
Feb 24, 2001·Life Sciences·R A Cunha, J A Ribeiro
Apr 3, 2001·Annual Review of Neuroscience·T V Dunwiddie, S A Masino
Nov 8, 2001·Trends in Pharmacological Sciences·E Schlicker, M Kathmann
Jul 12, 2002·Glia·T NishizakiN Saito
Sep 23, 2003·Brain Research·Nelson RebolaRodrigo A Cunha
Oct 3, 2003·Trends in Neurosciences·Eric A Newman
Nov 20, 2003·Trends in Neurosciences·Christopher A ReidJohn D Clements
Apr 7, 2004·The European Journal of Neuroscience·Yoshinobu KawamuraHiroyoshi Miyakawa
Citations
Jan 15, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alexander F HoffmanCarl R Lupica
Aug 19, 2014·Neurobiology of Disease·Antonella FerrantePatrizia Popoli
May 8, 2007·Brain Research·Satoshi ManitaHiroyoshi Miyakawa
Oct 20, 2007·Journal of Neurochemistry·Carolina LaderaJosé Sánchez-Prieto
Apr 29, 2006·Neuroscience Letters·Joo Han KimHung Seob Chung
Dec 21, 2013·Neuroscience·N M BannonM Volgushev
Jan 18, 2006·Brain Research·Syed I A ZaidiMusa A Haxhiu
Jul 26, 2007·The European Journal of Neuroscience·Ricardo MartínJosé Sánchez-Prieto
Apr 13, 2007·Physiological Reviews·Geoffrey Burnstock
Jan 15, 2014·Epilepsia·Feng GuJokūbas Žiburkus
Oct 17, 2018·Neuropharmacology·María-Dolores Muñoz, José M Solís
Jun 17, 2020·Neuroscience·Danqing YangDirk Feldmeyer
Feb 7, 2020·Epilepsy & Behavior : E&B·Lin ZhuQian Wu
Feb 20, 2021·European Journal of Pharmacology·Zi-Fan MaiChu-Hua Li