Adenosine A(1)-receptor-mediated tonic inhibition of glutamate release at rat hippocampal CA3-CA1 synapses is primarily due to inhibition of N-type Ca(2+) channels

European Journal of Pharmacology
Satoshi ManitaHiroyoshi Miyakawa

Abstract

The voltage-gated Ca(2+) channels responsible for synaptic transmission at CA3-CA1 synapses are mainly P/Q- and N-types. It has been shown that tonic inhibition of transmission due to activation of adenosine A(1) receptors occurs at this synapse. We have recently developed a technique to monitor synaptically released glutamate which is based on synaptically induced glial depolarisation. Using this technique, we have examined the effects of different voltage-gated Ca(2+) channel blockers on glutamate release. Under conditions in which the adenosine A(1) receptor was not blocked, omega-AgaIVA (a P/Q-type voltage-gated Ca(2+) channel blocker) suppressed synaptically induced glial depolarisation to a greater extent than omega-CgTxGVIA (an N-type voltage-gated Ca(2+) channel blocker) did. In contrast, in the presence of an adenosine A(1) receptor antagonist, omega-AgaIVA was less effective at suppressing synaptically induced glial depolarisation than omega-CgTxGVIA. These results indicate that, in the absence of adenosine A(1) receptor-mediated tonic inhibition, the contribution of N-type is much greater than that of P-type, and that N-types are the primary target of tonic inhibition in normal conditions in which adenosine A(1) rece...Continue Reading

References

Oct 1, 1985·The Journal of Physiology·G J AugustineS J Smith
Jun 1, 1996·Current Opinion in Neurobiology·H Reuter
May 1, 1997·Trends in Neurosciences·L G Wu, P Saggau
Feb 12, 1999·Brain Research. Brain Research Reviews·R Anwyl
Nov 11, 1999·The Journal of Membrane Biology·Y Momose-SatoK Kamino
Aug 11, 2000·Journal of Neurochemistry·J Cartmell, D D Schoepp
Feb 24, 2001·Life Sciences·R A Cunha, J A Ribeiro
Apr 3, 2001·Annual Review of Neuroscience·T V Dunwiddie, S A Masino
Nov 8, 2001·Trends in Pharmacological Sciences·E Schlicker, M Kathmann
Oct 3, 2003·Trends in Neurosciences·Eric A Newman
Nov 20, 2003·Trends in Neurosciences·Christopher A ReidJohn D Clements
Apr 7, 2004·The European Journal of Neuroscience·Yoshinobu KawamuraHiroyoshi Miyakawa

❮ Previous
Next ❯

Citations

Jan 15, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alexander F HoffmanCarl R Lupica
Oct 20, 2007·Journal of Neurochemistry·Carolina LaderaJosé Sánchez-Prieto
Apr 13, 2007·Physiological Reviews·Geoffrey Burnstock
Jun 17, 2020·Neuroscience·Danqing YangDirk Feldmeyer
Feb 7, 2020·Epilepsy & Behavior : E&B·Lin ZhuQian Wu
Feb 20, 2021·European Journal of Pharmacology·Zi-Fan MaiChu-Hua Li

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.