Adenosine A(2A)-cannabinoid CB(1) receptor interaction: an integrative mechanism in striatal glutamatergic neurotransmission

Brain Research
Maria Teresa TebanoP Popoli

Abstract

The striatum is a subcortical area involved in sensorimotor, cognitive and emotional processes. Adenosine A(2A) receptors (A(2A)Rs) are highly expressed in the striatum, and their ability to establish functional and molecular interactions with many other receptors attributes to a pivotal role in the modulation and integration of striatal neurotransmission. This review will focus on the interaction between A(2A)Rs and cannabinoid CB(1) receptors (CB(1)Rs), taking it as a paradigmatic example of synaptic integration. Indeed, A(2A)Rs can exert an opposite (permissive vs. inhibitory) influence on CB1-dependent synaptic effect. These apparently irreconcilable functions could depend on a different role of pre- vs. postsynaptic A(2A)Rs, on their interaction with other receptors (namely adenosine A(1), metabotropic glutamate 5 and dopamine D2 receptors), and on whether A(2A)Rs form or not heteromers with CB(1)Rs. Besides providing a good example of the intricate pattern of events taking place in striatal synapses, the A(2A)/CB(1)R interaction proves very informative to understand the physiology of the basal ganglia and the mechanisms of related diseases. This article is part of a Special Issue entitled: Brain Integration.

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Citations

Apr 9, 2014·Journal of Neuropathology and Experimental Neurology·Silvia CerriMarie Therese Armentero
Apr 17, 2017·Neuroscience and Biobehavioral Reviews·Bo HuQiang Wang
Nov 4, 2015·Journal of Neurochemistry·Valentina ChiodiMaria Rosaria Domenici
Jan 30, 2018·Frontiers in Pharmacology·Inmaculada Ballesteros-YáñezStefania Gessi
Aug 29, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Leigh V Panlilio, Zuzana Justinova
Nov 20, 2016·Clinical Pharmacology and Therapeutics·R Le BoisselierD Debruyne
Jan 20, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Estefanía MorenoManuel Guzmán
Jan 22, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Rafael Rivas-SantistebanRafael Franco

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