Adenosine A2A receptor-selective stimulation reduces signaling pathways involved in the development of intestine ischemia and reperfusion injury

Shock
Rosanna Di PaolaSalvatore Cuzzocrea

Abstract

In the present study, we tested the efficacy of treatment with the selective adenosine A2A receptor agonist 2-[p-(2-carboxyethyl)phenylethylamino]-50-ethylcarboxamidoadenosine (CGS 21680) on ischemia and reperfusion injury of the multivisceral organs. Ischemia and reperfusion injury was induced in mice by clamping both the superior mesenteric artery and the celiac artery for 30 min, followed thereafter by reperfusion. Sixty minutes after reperfusion, animals were killed for histological examination and biochemical studies. Injured vehicle-treated mice developed a significant increase of ileum TNF-alpha levels, myeloperoxidase activity, and marked histological injury and apoptosis. Ischemia and reperfusion injury of the multivisceral organs was also associated with significant mortality. Reperfused ileum sections from injured vehicle-treated mice showed positive staining for P-selectin and intercellular adhesion molecule 1. The intensity and degree of P-selectin and intercellular adhesion molecule 1 were markedly reduced in tissue sections from injured CGS 21680-treated mice. Ischemia and reperfusion-injured mice that have been treated with CGS 21680 showed also a significant reduction of neutrophil infiltration into the intesti...Continue Reading

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Citations

Jan 5, 2013·Journal of Cardiovascular Pharmacology·Bunyen TengS Jamal Mustafa
Aug 29, 2014·Mediators of Inflammation·Felicita PedataAlessia Melani
Jun 29, 2013·European Journal of Pharmacology·Hayri KertmenZeki Sekerci
Feb 13, 2021·Frontiers in Pharmacology·P BoknikU Gergs
Mar 25, 2011·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Joshua J FieldJoel Linden
Jul 16, 2011·European Journal of Pharmacology·Daniela ImpellizzeriSalvatore Cuzzocrea

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