Adenosine A2a receptors in the nucleus accumbens modulate prepulse inhibition of the startle response

Neuroreport
W Hauber, M Koch

Abstract

Prepulse inhibition (PPI) of the acoustic startle response (ASR) was disrupted by systemic administration of apomorphine (APO) (2 mg/kg, i.p.). Microinfusion of the selective adenosine A2a-recceptor agonist CGS21680 (0.05 microgram in 1.0 microliter per side) into the nucleus accumbens (NAc), had no significant effect in animals with systemic vehicle pretreatment, but significantly reversed the disruption of PPI in rats pretreated with APO. Adenosine is, therefore, involved in the control of PPI through its actions on A2a receptors in the NAc. APO-induced disruption of PPI is considered to represent an animal model useful for screening both typical and atypical antipsychotic agents. The present results add further support to the view that A2a-receptor agonists may be potentially useful antipsychotic agents.

References

Sep 16, 1991·Neuroscience Letters·S FerréK Fuxe
Jan 1, 1988·Psychopharmacology·R S MansbachD L Braff
Aug 1, 1993·Pharmacology, Biochemistry, and Behavior·G E MartinM F Jarvis
Mar 1, 1993·Pharmacology, Biochemistry, and Behavior·N R Swerdlow, M A Geyer
Jan 11, 1996·European Journal of Pharmacology·S H Kafka, R Corbett
Apr 1, 1996·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·F J WanN R Swerdlow

❮ Previous
Next ❯

Citations

Oct 27, 2006·Journal of Neural Transmission·K FuxeL F Agnati
Aug 26, 1998·Biological Psychiatry·M Koch, U Ebert
Nov 5, 1999·Pharmacology, Biochemistry, and Behavior·I C WeissA M Domeney
Dec 28, 1999·Brain Research. Brain Research Reviews·J L Moreau, G Huber
Aug 6, 2003·Behavioural Brain Research·Jian Hong WangMaarten van den Buuse
Aug 27, 1999·Progress in Neurobiology·M Koch
Sep 29, 1999·Progress in Neurobiology·P SvenningssonB B Fredholm
Apr 15, 2014·Psychopharmacology·Sylvain DubroquaPhilipp Singer
Jul 4, 2013·Biological Psychiatry·Catherine J WeiJiang-Fan Chen
Mar 2, 2005·Pharmacology & Therapeutics·Kui XuMichael Schwarzschild
Feb 15, 2011·Neuropharmacology·Detlev BoisonBenjamin K Yee
Sep 28, 2017·Molecular Psychiatry·A ChefferH Ulrich

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.