Adenosine A(2A) receptors modulate BDNF both in normal conditions and in experimental models of Huntington's disease.

Purinergic Signalling
R L PotenzaP Popoli

Abstract

Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, enhances synaptic transmission and regulates neuronal proliferation and survival. Functional interactions between adenosine A(2A) receptors (A(2A)Rs) and BDNF have been recently reported. In this article, we report some recent findings from our group showing that A(2A)Rs regulate both BDNF functions and levels in the brain. Whereas BDNF (10 ng/ml) increased the slope of excitatory postsynaptic field potentials (fEPSPs) in hippocampal slices from wild-type (WT) mice, it was completely ineffective in slices taken from A(2A)R knock-out (KO) mice. Furthermore, enzyme immunoassay studies showed a significant reduction in hippocampal BDNF levels in A(2A)R KO vs. WT mice. Having found an even marked reduction in the striatum of A(2A)R KO mice, and as both BDNF and A(2A)Rs have been implicated in the pathogenesis of Huntington's disease (HD), an inherited striatal neurodegenerative disease, we then evaluated whether the pharmacological blockade of A(2A)Rs could influence striatal levels of BDNF in an experimental model of HD-like striatal degeneration (quinolinic acid-lesioned rats) and in a transgenic mice model of HD (R6/2 mice). In both QA-lesioned rats a...Continue Reading

References

Sep 12, 1995·Proceedings of the National Academy of Sciences of the United States of America·M KorteT Bonhoeffer
Oct 29, 1996·Proceedings of the National Academy of Sciences of the United States of America·M KorteT Bonhoeffer
Jun 18, 1999·Science·L Boulanger, M M Poo
Aug 6, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J H ChaA B Young
Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·F S Lee, M V Chao
Mar 20, 2001·Nature Reviews. Neuroscience·M M Poo
Aug 25, 2001·Annual Review of Neuroscience·E J Huang, L F Reichardt
Dec 4, 2002·Nature Reviews. Neuroscience·Carlos Vicario-AbejónMenahem Segal
Mar 29, 2003·Learning & Memory·Bai Lu
Mar 27, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Maria José DiógenesJoaquim Alexandre Ribeiro
Oct 7, 2004·Current Opinion in Neurobiology·Yury KovalchukArthur Konnerth
Dec 15, 2004·The Journal of Cell Biology·Shingo SuzukiMasami Kojima
Jun 22, 2005·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Chiara ZuccatoElena Cattaneo
Jul 26, 2005·Trends in Neurosciences·Guhan Nagappan, Bai Lu
Aug 16, 2005·Progress in Neurobiology·Clive R Bramham, Elhoucine Messaoudi
Nov 17, 2005·Nature Reviews. Neuroscience·Elena CattaneoMarzia Tartari
Mar 8, 2006·Experimental Neurology·Jian Hong WangMaarten van den Buuse
May 3, 2006·Neurobiology of Disease·Alessia TarditiMaria P Abbracchio
Jun 23, 2006·Neuroscience Letters·Paula A PousinhaAna M Sebastião
Jul 11, 2006·Neurobiology of Learning and Memory·Lydia Giménez-LlortMichael Bader
Feb 17, 2007·Progress in Neurobiology·Patrizia PopoliMaria P Abbracchio
Mar 24, 2007·Progress in Neurobiology·Chiara Zuccato, Elena Cattaneo
Apr 20, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Gary LynchDanielle A Simmons
Sep 28, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Richard KolarowVolkmar Lessmann

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Citations

Mar 30, 2010·Acta Physiologica·J A Ribeiro, A M Sebastião
Jun 6, 2012·Parkinson's Disease·Veronica GhiglieriPaolo Calabresi
Oct 7, 2009·Neurobiology of Disease·Alberto MartirePatrizia Popoli
Jan 11, 2017·Human Molecular Genetics·Yu-Han KaoChun-Jung Lin
Jan 31, 2013·Journal of Neuroscience Research·Rosa Luisa PotenzaPatrizia Popoli
Apr 26, 2018·Frontiers in Pharmacology·Ágatha Oliveira-GiacomelliHenning Ulrich
Jul 20, 2018·Journal of Caffeine and Adenosine Research·David BlumPatrizia Popoli
Jun 11, 2009·British Journal of Pharmacology·Ana M Sebastião, Joaquim A Ribeiro
Aug 17, 2010·Pharmacology & Therapeutics·Megan J DowieMichelle Glass

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Methods Mentioned

BETA
transgenic

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