Adenosine and ATP: traffic regulators in the kidney

The Journal of Clinical Investigation
Wilhelm Kriz

Abstract

Glomerular filtration in the kidney is a continuous process that acts in concert with tubular reabsorption to prevent derangements of body fluid composition. Filtration is regulated by systemic factors, but it is also controlled by an intrinsic mechanism based on the anatomical connection between the distal nephron and the glomerular arterioles. Facing the threat of urinary salt loss, this mechanism causes vasoconstriction and reduces filtration by generating adenosine through the hydrolysis of nucleotide precursors such as 5'-AMP and possibly ATP.

References

Mar 1, 1990·The American Journal of Physiology·J SchnermannJ P Briggs
Jan 1, 1980·The International Journal of Biochemistry·H OsswaldH Hermes
Dec 1, 1996·Journal of Autonomic Pharmacology·H OsswaldB Mühlbauer
Jul 21, 2000·The Journal of Clinical Investigation·S ThomsonV Vallon
Dec 9, 2000·Naunyn-Schmiedeberg's Archives of Pharmacology·H Zimmermann
May 16, 2001·American Journal of Physiology. Renal Physiology·E W Inscho
Aug 16, 2001·Proceedings of the National Academy of Sciences of the United States of America·D SunJ Schnermann
Jun 19, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Akira Nishiyama, L Gabriel Navar
Jun 19, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jurgen Schnermann
Mar 26, 2003·Proceedings of the National Academy of Sciences of the United States of America·Phillip Darwin BellYasunobu Okada
Jul 4, 2003·The Journal of Clinical Investigation·Janos Peti-PeterdiP Darwin Bell
Sep 30, 2003·Journal of the American Society of Nephrology : JASN·Pernille B HansenJurgen Schnermann
Dec 18, 2003·The Journal of Clinical Investigation·Edward W InschoRichard J Evans
Mar 11, 2004·American Journal of Physiology. Renal Physiology·Alex PaliegeTianxin Yang
Jun 8, 2004·American Journal of Physiology. Renal Physiology·Frank SchwedaArmin Kurtz
Sep 3, 2004·The Journal of Clinical Investigation·Hayo CastropJurgen Schnermann

❮ Previous
Next ❯

Citations

May 5, 2012·Purinergic Signalling·Herbert ZimmermannNorbert Sträter
Nov 23, 2013·Purinergic Signalling·Geoffrey BurnstockMatthew A Bailey
Feb 2, 2010·Mayo Clinic Proceedings·Gautam V RamaniMandeep R Mehra
Sep 1, 2015·Pharmacological Reports : PR·Paulina ZukowskaEwa M Slominska
Sep 3, 2009·Current Heart Failure Reports·Ravi V Shah, Michael M Givertz
May 10, 2011·Heart Failure Reviews·Branko BraamCarlo Gaillard
Jun 30, 2016·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Ali Mirza OnderRobert Gustafson
Jan 30, 2009·American Journal of Physiology. Renal Physiology·Natasha CookDavid A Power
Sep 15, 2020·Frontiers in Pharmacology·Colleen S CurranJeffrey B Kopp

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Physiological Reviews
Volker VallonHartmut Osswald
American Journal of Physiology. Heart and Circulatory Physiology
Huda E TawfikS J Mustafa
Naunyn-Schmiedeberg's Archives of Pharmacology
K N Klotz
© 2021 Meta ULC. All rights reserved