PMID: 1203630Nov 1, 1975Paper

Adenosine and dipyridamole actions and interactions on isolated coronary artery strips of cattle

British Journal of Pharmacology
S Kalsner

Abstract

1 The actions and interactions of adenosine and dipyridamole were investigated on isolated strips of coronary arteries of beef cattle. It was found that small diameter arteries (about 0.5-1.0 mm o9d.), raised to a moderate level of tone with potassium, responded with relaxation to low concentrations of adenosine. 2 Dipyridamole, over a broad concentration range (6.0 X 10(-8)-2.0 X 10(-5)M), enhanced these responses, shifting the adenosine concentration-response curve (3.7 X 10(-8)-1.1 X 10(-4)M) considerably to the left. In contrast, inhibitory concentrations-response curves to sodium nitrite and to noradrenaline were not materially altered by dipyridamole. 3 Studies of the uptake of [3H]-adenosine revealed a rapid uptake of the nucleoside by coronary artery strips, which was inhibited by dipyridamole (6.0X 10(-8)-2.0X10(-5)M); but this may not be sufficient to account fully for the observed sensitization. 4 It is concluded that the regulation of adenosine responses and the action of dipyridamole in the heart involve a more direct association with coronary vascular tissue than has been previously appreciated.

References

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Citations

Jan 1, 1985·Psychopharmacology·S K Kulkarni, A K Mehta
Dec 15, 1976·Biochemical Pharmacology·M Huang, G I Drummond
Sep 1, 1978·Prostaglandins and Medicine·S Kalsner
Jul 1, 1984·Pharmacological Research Communications·R C MillerR G Goldie
Feb 1, 1980·British Journal of Pharmacology·S FujitaM Takei
Aug 1, 1981·British Journal of Pharmacology·G Burnstock, P Meghji
Jun 1, 1981·Journal of Autonomic Pharmacology·J Willemot, D M Paton
Mar 1, 1987·Acta Physiologica Scandinavica·T B ConradsonP J Barnes
Aug 1, 1983·The Journal of Pharmacy and Pharmacology·M A Oriowo
Jan 1, 1980·British Journal of Pharmacology·A S Clanachan, R J Marshall
Sep 15, 1985·Biochemical Pharmacology·S M JarvisA S Ng
Dec 1, 1983·Circulation·T H Hintze, S F Vatner
Aug 6, 1999·Stroke; a Journal of Cerebral Circulation·H ItoH Iida
Sep 20, 2000·American Journal of Physiology. Heart and Circulatory Physiology·L J RubinA W Jones
May 1, 1983·Progress in Cardiovascular Diseases·G J Goldman, A D Pichard

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