Adenosine and glutamate extracellular concentrations and mitogen-activated protein kinases in the striatum of Huntington transgenic mice. Selective antagonism of adenosine A2A receptors reduces transmitter outflow

Neurobiology of Disease
Marco GianfriddoF Pedata

Abstract

The basal ganglia and deep layers of cerebral cortex neurodegeneration typically characterize the postmortem brain of Huntington disease (HD) patients. In this study, we employed 10- to 11-week-old transgenic HD mice (R6/2 line), in which the striatal adenosine extracellular levels, measured using the microdialysis technique, are significantly increased in comparison to wild-type mice. An increase in striatal adenosine is probably a precocious index of mitochondrial dysfunction that is described in both the postmortem brain of HD patients and transgenic mice striatal cells. The adenosine increase is matched by activation of the p38 mitogen-activated protein kinase (MAPK) in the striatal neurons of R6/2 mouse but not in the cortex. This result indicates that p38 MAPK is a correlate of striatal damage and suggests a role for p38 in the striatal neuron suffering and apoptosis described in this disease. The selective adenosine A(2A) receptor antagonist SCH 58261, administered through microdialysis fiber into the striatum, significantly decreases the outflow of glutamate in R6/2 mice. Antagonism of adenosine A(2A) receptors might be regarded as potentially useful in the treatment of this disease to control striatal excitotoxicity.

References

Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·A ReinerA B Young
Nov 24, 1995·Science·Z XiaM E Greenberg
Dec 12, 1995·European Journal of Pharmacology·P PopoliG Ricciarello
Aug 15, 1997·The Journal of Biological Chemistry·J L KummerK A Heidenreich
Dec 16, 1998·Brain Research·O V VitoloP Calissano
Feb 24, 1999·Journal of Neuropathology and Experimental Neurology·E SappM DiFiglia
Sep 16, 1999·Cellular and Molecular Life Sciences : CMLS·L A Tibbles, J R Woodgett
Jun 17, 2000·Trends in Neurosciences·M F Beal
May 11, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Andre KuliszPaul T Schumacker
Jul 4, 2002·Neuromolecular Medicine·Tamara KiechleRobert J Ferrante
Jul 24, 2002·Brain : a Journal of Neurology·P F BehrensG B Landwehrmeyer
Aug 1, 2002·Nature Neuroscience·Elena Cattaneo, Paolo Calabresi
Aug 30, 2002·The Journal of Biological Chemistry·Donato GoffredoElena Cattaneo
Sep 13, 2002·The Journal of Biological Chemistry·Zhi-Liang WuDonna Bozyczko-Coyne
Oct 23, 2002·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Kohsuke Takeda, Hidenori Ichijo

❮ Previous
Next ❯

Citations

Sep 5, 2012·Molecular Neurobiology·Pawel M SwitonskiMaciej Figiel
Apr 23, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shuang-Shuang DaiJiang-Fan Chen
Jun 3, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ana SaavedraEsther Pérez-Navarro
Feb 9, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·David M TaylorRuth Luthi-Carter
Feb 26, 2014·European Journal of Nuclear Medicine and Molecular Imaging·Andreas MatuschAndreas Bauer
Feb 24, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Gennaro PaganoMarios Politis
Apr 3, 2010·Pharmacological Reports : PR·Puneet KumarAnil Kumar
Jan 7, 2016·Frontiers in Neuroscience·Jan Lewerenz, Pamela Maher
Aug 17, 2010·Pharmacology & Therapeutics·Megan J DowieMichelle Glass
Feb 19, 2008·Archives of Medical Research·Ana María Estrada SánchezLourdes Massieu
Feb 23, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Minhee JangIk-Hyun Cho
Aug 27, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Edward J Wild, Sarah J Tabrizi
May 3, 2006·Neurobiology of Disease·Alessia TarditiMaria P Abbracchio
Apr 15, 2005·Neurological Research·F PedataA Melani
Jan 1, 2015·Nature Reviews. Disease Primers·Gillian P BatesSarah J Tabrizi
Jul 26, 2016·Frontiers in Human Neuroscience·Kendra D Bunner, George V Rebec
Feb 17, 2007·Progress in Neurobiology·Patrizia PopoliMaria P Abbracchio
Apr 26, 2019·International Journal of Molecular Sciences·Raquel Pérez-SenEsmerilda G Delicado
Jul 17, 2019·Current Pharmaceutical Design·Hira ChoudhuryBapi Gorain
Jan 11, 2017·Human Molecular Genetics·Yu-Han KaoChun-Jung Lin
Oct 5, 2016·Experimental and Therapeutic Medicine·Wen-Juan HuangXia Zhang
Oct 6, 2020·Frontiers in Molecular Neuroscience·Prita R AsihArne Ittner
Apr 26, 2018·Frontiers in Pharmacology·Ágatha Oliveira-GiacomelliHenning Ulrich
Feb 7, 2019·Nature Structural & Molecular Biology·Fernando Aprile-GarciaRitwick Sawarkar
Jul 20, 2018·Journal of Caffeine and Adenosine Research·David BlumPatrizia Popoli
Jul 3, 2021·International Journal of Molecular Sciences·Marta TomczykRyszard T Smolenski

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

Alzheimer's Disease: Animal Models

Alzheimer's disease is a neurodegenerative disease which can be studied using various experimental systems. This feed focuses on animal models used for Alzheimer's disease research.