Adenosine and migraine

The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
R GuieuH Rochat

Abstract

Adenosine is a powerful natural vasodilator that participates in the control of cerebral and meningeal blood flow. In this context, it could be involved in the pathophysiology of migraine, since it was previously reported that intravenous adenosine can precipitate crises in migraine patients. We have investigated circulating adenosine levels in 12 patients suffering from migraine without aura, during crises and in crisis-free periods, and have compared the levels noted to those of a population of 10 controls. To determine if there are interactions between adenosine and serotonin, we examined the effect of adenosine and antagonists on the uptake and the release of (14C) serotonin by platelets. We have reached a dual conclusion: 1) during migraine headaches there is an increase (mean 68%) in circulating adenosine levels and this increase may participate in cephalalgia; 2) activation of A2 receptors by adenosine causes a dose-dependent serotonin uptake by platelets. This inhibition of uptake could participate in the rapid elimination of serotonin in migraine sufferers. As a result of this, the use of adenosine antagonists could be an effective complementary treatment for migraine.

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Citations

Dec 29, 2010·International Journal of Vascular Medicine·Darío EcheverriAngélica Prieto
Mar 25, 2017·Brain Sciences·Nathan T FriedMichael L Oshinsky
Apr 14, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Nilufer YalcinKatharina Eikermann-Haerter
Dec 19, 2019·Frontiers in Neurology·Karl B Alstadhaug, Anna P Andreou
Jul 8, 2020·The Journal of Headache and Pain·Andrea NegroKatharina Eikermann-Haerter
Jul 6, 2020·Pain and Therapy·Elena A KorabelnikovaAda R Artemenko
Apr 21, 2005·Cephalalgia : an International Journal of Headache·S BirkJ Olesen
Aug 5, 2006·Cephalalgia : an International Journal of Headache·C KruuseJ Olesen
Jul 24, 2014·Cephalalgia : an International Journal of Headache·Philip R Holland
Mar 29, 2014·Food & Function·Iziar A LudwigAlan Crozier
May 29, 2018·The Journal of Headache and Pain·Kristian A HaanesAntoinette MaassenVanDenBrink
Aug 1, 2020·Nutrients·Magdalena NowaczewskaWojciech Kaźmierczak
Jul 16, 2008·Current Pain and Headache Reports·Robert E Shapiro
Oct 8, 2016·Current Neurology and Neuroscience Reports·Zoya ZaeemEsma Dilli
Jul 22, 2014·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·G DavidaiH-C Diener
Jun 3, 2021·International Journal of Molecular Sciences·Marta Waliszewska-ProsółSławomir Budrewicz
Jul 27, 2021·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Mohammed ElsadanyW Lane Duvall

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