Adenosine and renal sodium handling: direct natriuresis and renal nerve-mediated antinatriuresis.

Journal of the American Society of Nephrology : JASN
R Fransen, H A Koomans

Abstract

Adenosine infusion is associated with natriuresis as well as antinatriuresis. The physiologic significance of these opposite effects is unknown but may have to do with different conditions of ischemia, in which adenosine accumulates. These effects were characterized in the rat. First, intrarenal and systemic infusions within one animal were performed. Infusing 10 micrograms/min into the left renal artery increased sodium by approximately 50%; however, the subsequent infusion of 50 micrograms/min into the thoracic aorta decreased sodium excretion by approximately 60%, in association with a small reduction of blood pressure. Second, to explore the effect of intrarenal adenosine in tubular sodium handling, free-flow micropuncture experiments were performed. The intrarenal infusion of 10 micrograms/min again caused sodium excretion, but no change in GFR, volume, and sodium deliveries up to the early distal tubule was found. Apparently, the direct effect of adenosine in the kidney is sodium excretion, by a tubular action beyond the early distal tubule. Third, to further characterize the indirect effect, which apparently is sodium retention, adenosine was infused systemically at low rates, in order to avoid a decrease in blood pressu...Continue Reading

Citations

Jan 3, 2001·Journal of the American Society of Nephrology : JASN·Takanobu TakezakoKikuo Arakawa
Nov 7, 2001·Autonomic Neuroscience : Basic & Clinical·Z MingW W Lautt
Jun 4, 2002·The Journal of Physiology·Francesca Di SoleCorinna Helmle-Kolb
Mar 6, 1998·Journal of Hypertension·G PanzacchiA Stella
Feb 1, 2000·The American Journal of the Medical Sciences·D C Brater
Jun 24, 2003·Journal of the American Society of Nephrology : JASN·Francesca Di SoleCorinna Helmle-Kolb
May 1, 2007·The American Journal of Medicine·Hyon K Choi, Earl S Ford
Jul 29, 2008·Current Opinion in Nephrology and Hypertension·Francesca Di Sole
Sep 19, 2008·Journal of the American Society of Nephrology : JASN·Markus P SchlaichGavin W Lambert

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