Adenosine and tubuloglomerular feedback

Blood Purification
H OsswaldV Vallon

Abstract

During the past 16 years numerous studies have shown that adenosine is present in the normoxic kidney and accumulates when ATP hydrolysis prevails over ATP synthesis. Adenosine can induce renal vasoconstriction and a fall in glomerular filtration rate (GFR). The tubuloglomerular feed-back (TGF) mechanism refers to a series of events whereby changes in the NaCl concentration in the tubular fluid at the end of the thick ascending limb of Henle's loop are sensed by the macula densa which then elicits a twofold response in the juxtaglomerular apparatus: a change in the afferent arteriolar tone and GFR and an alteration in renin secretion from granular cells. While an increase in late proximal tubular flow rate, which increases the NaCl concentration and probably transport across the macula densa, lowers GFR and renin secretion, a low NaCl concentration at the macula densa elicits the opposite effects. One important role of the TGF response is to keep the fluid and electrolyte delivery to the distal tubule within certain limits, so that this part of the nephron can accomplish the fine adjustments in reabsorption to meet body needs. In this regard the TGF mechanism serves to establish an appropriate balance between nephron filtration...Continue Reading

Citations

Jul 20, 2007·Molecular and Cellular Biochemistry·Carlos Martínez-SalgadoJosé M López-Novoa
Nov 4, 2000·Expert Opinion on Investigational Drugs·R Venkataraman, J A Kellum
Oct 8, 2014·Acta Physiologica·M M Rabadi, H T Lee
Dec 14, 2004·Journal of the American Society of Nephrology : JASN·Peter BenoehrJorg T Hartmann
Jan 18, 2006·The Journal of Pharmacology and Experimental Therapeutics·Almut GrenzHartmut Osswald
Jul 26, 2013·American Journal of Physiology. Renal Physiology·M Cecilia Ortiz-CapisanoWilliam H Beierwaltes
Apr 18, 2020·Physiological Research·Z GuanE W Inscho
Oct 2, 2002·Acta Physiologica Scandinavica·A E G PerssonA Ollerstam
Apr 19, 2002·Journal of the American Society of Nephrology : JASN·Ruisheng LiuA Erik G Persson

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