PMID: 9553651Apr 29, 1998Paper

Adenosine deaminase and human reproduction: a comparative study of fertile women and women with recurrent spontaneous abortion

American Journal of Reproductive Immunology : AJRI
M NicotraE Bottini

Abstract

We have investigated the possible role of adenosine deaminase (ADA) genetic polymorphism in human fertility through a comparative study of couples with recurrent spontaneous abortion (RSA) and healthy puerperae. Adenosine deaminase phenotype has been determined in 209 women with repeated episodes of unexplained spontaneous abortion (RSA) and their husbands, as well as in 115 healthy pregnant women from the population of Rome. An independent sample of 286 puerperae along with their newborn infants in the population of Penne was also studied. The proportion of carriers of ADA*2 allele, which is associated with the lowest enzymatic activity, is lower among women with RSA than among healthy pregnant women from the same population of Rome. Preliminary observations suggest a protective effect of ADA*2 against the development of autoantibodies in RSA. Such an effect seems to be mediated by an interaction with AB0 blood groups. In the population of Penne the proportion of women carrying ADA*2 allele is higher among those who have had two or more previously born children than among women with only one or no children. The data suggest that women carrying the ADA*2 allele are better protected against the spontaneous loss of embryos and ha...Continue Reading

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Citations

Feb 4, 2005·Archives of Gynecology and Obstetrics·Irfan KutlarMehmet Tarakcioglu
Jun 13, 2009·Archives of Gynecology and Obstetrics·Mojgan MokhtariSaeid Ghavami
Dec 11, 1999·Fertility and Sterility·N BottiniF Gloria-Bottini
Mar 27, 2013·Archives of Physiology and Biochemistry·Ashish Anantrao Jadhav, Anuradha Jain
May 25, 2010·Metabolism: Clinical and Experimental·Valerio Napolioni
Jan 31, 2012·American Journal of Human Biology : the Official Journal of the Human Biology Council·Fulvia Gloria-BottiniAndrea Magrini
May 20, 2014·Transactions of the Royal Society of Tropical Medicine and Hygiene·Ana Carolina Bonini DomingosLuiz Carlos de Mattos
Jun 12, 2004·Gynecologic and Obstetric Investigation·Soultana HitoglouJohn Tzafettas
Jun 15, 2007·American Journal of Reproductive Immunology : AJRI·M NicotraF Gloria-Bottini

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