Adenosine deaminase-related growth factors stimulate cell proliferation in Drosophila by depleting extracellular adenosine

Proceedings of the National Academy of Sciences of the United States of America
Michal ZurovecPeter J Bryant

Abstract

We describe a protein family in Drosophila containing six adenosine deaminase-related growth factors (ADGFs), which are homologous to a mitogenic growth factor discovered in conditioned medium from cells of a different fly species, Sarcophaga. Closely related proteins have been identified in other animals, and a human homolog is implicated in the genetic disease Cat-Eye Syndrome. The two most abundantly expressed ADGFs in Drosophila larvae are ADGF-A, which is strongly expressed in the gut and lymph glands, and ADGF-D, which is mainly expressed in the fat body and brain. Recombinant ADGF-A and ADGF-D are active adenosine deaminases (ADAs), and they cause polarization and serum-independent proliferation of imaginal disk and embryonic cells in vitro. The enzymatic activity of these proteins is required for their mitogenic function, making them unique among growth factors. A culture medium prepared without adenosine, or depleted of adenosine by using bovine ADA, also stimulates proliferation of imaginal disk cells, and addition of adenosine to this medium inhibits proliferation. Thus ADGFs secreted in vivo may control tissue growth by modulating the level of extracellular adenosine.

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Citations

Oct 26, 2005·Journal of Molecular Evolution·Stephanie A MaierHeather E McDermid
Feb 12, 2010·The Journal of Biological Chemistry·Anton V ZavialovAndrey V Zavialov
Feb 19, 2009·Acta Physiologica·G Burnstock, A Verkhratsky
Feb 22, 2012·Biochemistry. Biokhimii︠a︡·Ye G SargisovaH A Harutyunyan
May 24, 2005·PLoS Biology·Tomas DolezalPeter J Bryant
Jan 24, 2012·Insect Biochemistry and Molecular Biology·Jana FleischmannovaMichal Zurovec
Oct 15, 2011·Insect Biochemistry and Molecular Biology·Michaela FenckovaTomas Dolezal
Mar 21, 2007·Insect Biochemistry and Molecular Biology·Eva DolezelovaMichal Zurovec
Apr 5, 2005·Insect Biochemistry and Molecular Biology·Eva DolezelovaPeter J Bryant
Oct 3, 2006·Biochemical and Biophysical Research Communications·Yasuhiro TanakaKoichi J Homma
Apr 2, 2002·American Journal of Human Genetics·Heather E McDermid, Bernice E Morrow
Jul 1, 2012·JAK-STAT·Marc Amoyel, Erika A Bach
Sep 25, 2014·Frontiers in Plant Science·Miguel Moreno-GarcíaHumberto Lanz-Mendoza
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Dec 20, 2019·Proceedings of the National Academy of Sciences of the United States of America·Chiwei XuNorbert Perrimon
Jun 2, 2005·The Biochemical Journal·Andrey V Zavialov, Ake Engström
Dec 20, 2018·Immunological Reviews·Leen MoensIsabelle Meyts

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