PMID: 8607668Apr 1, 1996Paper

Adenosine effectively controls pulmonary hypertension after cardiac operations

The Annals of Thoracic Surgery
D A FullertonR C McIntyre

Abstract

Pulmonary hypertension secondary to increased pulmonary vascular resistance may greatly complicate the perioperative management of patients having cardiac operations. Adenosine may have a therapeutic role as a selective pulmonary vasodilator. The purpose of this study was to examine the pulmonary hemodynamic effects of a central venous infusion of adenosine in cardiac operative patients with pulmonary hypertension. Ten cardiac patients with pulmonary hypertension (age, 62 +/- 6 years) were studied in the operating room under general anesthesia after weaning from cardiopulmonary bypass. Cardiac output, pulmonary vascular resistance, systemic vascular resistance, mean pulmonary arterial pressure, and mean systemic arterial pressure were determined before, during, and after central venous infusion of adenosine (50 micrograms x kg-1 x min -1) for 15 minutes. Statistical analysis was by analysis of variance, and significance was accepted at p < 0.05. Adenosine produced significant pulmonary vasodilation. Mean pulmonary arterial pressure was lowered from 36 +/- 1 to 28 +/- 2 mm Hg (p < 0.05), and pulmonary vascular resistance was lowered from 560 +/- 30 to 260 +/- 30 dynes x s x cm-5 (p < 0.05) during adenosine administration. At the...Continue Reading

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Mar 1, 1996·The Journal of Surgical Research·D A FullertonR C McIntyre

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Citations

Oct 5, 2001·Journal of the American College of Cardiology·B Stobierska-DzierzekR E Michler
Jan 29, 2003·Heart Disease·Sheldon Goldstein, David Amar
Sep 23, 2010·Critical Care : the Official Journal of the Critical Care Forum·Laura C PriceStephen J Brett
Oct 17, 2002·Circulation Journal : Official Journal of the Japanese Circulation Society·Kimiaki KomukaiSeibu Mochizuki
May 6, 2010·Annals of Cardiac Anaesthesia·Deepak K Tempe
Jun 10, 1998·Seminars in Thoracic and Cardiovascular Surgery·J C Madsen, W M Daggett
Mar 11, 2015·Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia·Baris AkcaBektas Battaloglu
Feb 25, 2009·Medical Hypotheses·Stevan P TofovicOlga Rafikova
Apr 28, 2007·Seminars in Pediatric Surgery·Hadi Mohseni-Bod, Desmond Bohn
Jun 23, 2004·Current Problems in Surgery·A Thomas PezzellaRobert A Lancey
May 1, 1997·The Annals of Thoracic Surgery·D A FullertonR C McIntyre
May 7, 2013·Expert Opinion on Therapeutic Targets·Massimo CarusoRiccardo Polosa
May 31, 2007·Seminars in Cardiothoracic and Vascular Anesthesia·Kathirvel Subramaniam, Jean-Pierre Yared
Aug 12, 2016·Turkish Journal of Medical Sciences·Barış AkçaNevzat Erdil
Jan 12, 2000·Journal of Cardiovascular Pharmacology·M B SpaldingS Alahuhta
Jun 22, 2010·Cardiovascular Therapeutics·Gan Hui-li
Sep 2, 2020·Journal of the American Heart Association·Zongye CaiZhichao Zhou
Jun 14, 2000·Journal of Applied Physiology·K KicheninM Seman

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