Adenosine has divergent effects on deoxyribonucleic acid synthesis in FRTL5 cells: inhibition of thyrotropin-stimulated and potentiation of insulin-like growth factor-I-stimulated thymidine incorporation.

Endocrinology
A C MosesA G Frauman

Abstract

Adenosine inhibits TSH-stimulated [3H]thymidine incorporation into DNA in FRTL5 thyroid follicular cells by both inhibiting cAMP generation and acting at a locus beyond adenylate cyclase. On the other hand, adenosine markedly potentiates DNA synthesis in FRTL5 stimulated by insulin-like growth factor-I (IGF-I). The mechanisms of this latter effect are unknown, but require the coincubation of adenosine and IGF-I and not mediated by an increase in intracellular cAMP concentration. Adenosine increases the maximal response of FRTL5 to [3H]thymidine incorporation stimulated by IGF-I and increases the sensitivity of FRTL5 to IGF-I. These effects of adenosine are reflected by an increase in nuclear labeling as well as by an increase in [3H]thymidine incorporation into DNA. Adenosine also plays a role as an autocrine growth factor in FRTL5, since adenosine deaminase increases the response of these cells to TSH. The effects of adenosine on both TSH- and IGF-I-stimulated DNA synthesis are shared by guanosine and inosine, although with different potencies for the various guanine nucleosides. Inosine potentiates IGF-I-stimulated DNA synthesis, but inhibits TSH-stimulated DNA synthesis only weakly. Adenosine interacts with multiple receptor...Continue Reading

Citations

Feb 1, 1996·Journal of Cellular Physiology·K TörnquistB Dugué
Dec 1, 1996·Journal of Cellular Physiology·M VainioK Törnquist
Apr 1, 1994·Molecular and Cellular Endocrinology·M C Eggo, M C Sheppard
Jan 5, 2000·Molecular and Cellular Endocrinology·N HariiT Onaya
May 12, 2000·British Journal of Pharmacology·M VainioK Törnquist
Sep 4, 1999·Japanese Circulation Journal·M KitakazeM Hori

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