Adenosine in inflammatory joint diseases.

Purinergic Signalling
Edwin S L ChanB N Cronstein

Abstract

Inflammatory joint diseases are a group of heterogeneous disorders with a variety of different etiologies and disease manifestations. However, there are features that are common to all of them: first, the recruitment of various inflammatory cell types that are attracted to involved tissues over the course of the disease process. Second, the treatments used in many of these diseases are commonly medications that suppress or alter immune function. The demonstration that adenosine has endogenous anti-inflammatory functions and that some of the most commonly used anti-rheumatic medications exert their therapeutic effects through stimulation of adenosine release suggest an important role for purinergic signaling in inflammatory rheumatic disorders.

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Citations

Dec 2, 2009·Modern Rheumatology·Edwin S L Chan, Bruce N Cronstein
Aug 15, 2013·Purinergic Signalling·Geoffrey BurnstockIsabel R Orriss
Apr 4, 2012·Journal of Medicinal Chemistry·Pier Giovanni BaraldiKatia Varani
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Aug 13, 2014·Nature Reviews. Rheumatology·Heinrike SchmelingMarvin J Fritzler
Mar 5, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Tian-Shen YeJian-Qiao Fang
Mar 5, 2016·European Journal of Nutrition·Anthony ZulliPeter Kruzliak
Aug 5, 2017·International Journal of Molecular Sciences·Woonhyeok JeongWon Jai Lee
May 23, 2020·International Journal of Molecular Sciences·Francisco Miguel Conesa-BuendíaAránzazu Mediero
May 2, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·S JayashreeDipita Bhakta-Guha

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