Abstract
While adenosine effectively terminates most supraventricular tachycardias (SVT), rare case reports have demonstrated its proarrhythmic potential, including induction of ventricular tachycardia (VT). The aim of this study was to define the proarrhythmic effects of adenosine in a large, unselected population. During a 5-year period, adenosine was used (average dose 9.7 mg) in the emergency room to manage 187 episodes of tachycardia in 127 patients. In two thirds of the cases, adenosine induced ventricular ectopy following successful termination of SVT, including premature ventricular complexes (PVC) and nonsustained VT. The adenosine induced PVCs and VT were transient and self-terminating. More than half had a right bundle branch block morphology with a superior axis that suggested an origin in the inferior left ventricular septum. In conclusion, although adenosine is commonly used in clinical practice to treat SVTs, we found that it induced PVCs and VT in two thirds of the patients. The high incidence of ventricular arrhythmias following adenosine infusion was surprising but did not require further intervention. These arrhythmias appeared to frequently originate from the inferior left ventricular septum, suggesting that this are...Continue Reading
Citations
Sep 19, 2003·Journal of the American College of Cardiology·Eric N PrystowskyAndrew A Wolff
Jun 23, 2004·Emergency Medicine Journal : EMJ·M L Mallet
Oct 22, 2010·Circulation·Monica E KleinmanUNKNOWN Pediatric Basic and Advanced Life Support Chapter Collaborators
Oct 20, 2010·Pediatrics·Monica E KleinmanUNKNOWN Pediatric Basic and Advanced Life Support Chapter Collaborators
Jul 9, 2010·Future Cardiology·Ayman El-Menyar, Abdulrazzak Gehani
Jul 11, 2009·Expert Review of Cardiovascular Therapy·Komandoor SrivathsanFarouk Mookadam
Oct 20, 2010·Resuscitation·Allan R de CaenUNKNOWN Paediatric Basic and Advanced Life Support Chapter Collaborators
Nov 17, 2007·International Journal of Cardiology·Martin HuemerWilhelm Haverkamp
Sep 16, 2009·Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine·Keith M SwetzThomas J Smith
Oct 7, 2009·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Cengizhan TürkoğluNilgün Incesoy
Nov 1, 2008·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Cagatay ErtanBülent Ozin
May 12, 2004·Resuscitation·Chu-Lin Tsai, Wei-Tien Chang
Jan 13, 2006·International Journal of Cardiology·Yushu LiJunguo Yang
Aug 4, 2016·Critical Care Nursing Clinics of North America·Aimee Lee, David Pickham
Aug 27, 2016·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·R PrisecaruB Schwagten
May 24, 2014·Journal of Cardiovascular Pharmacology and Therapeutics·Ersöz Gonca, Faruk Darıcı
Jan 23, 2017·Journal of Medical Case Reports·Christopher A RajkumarPhang Boon Lim
Feb 7, 2002·Pharmacoepidemiology and Drug Safety
Oct 16, 2004·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Dipen ShahMichel Haissaguerre
Nov 21, 2007·Emergency Medicine Australasia : EMA·Martyn G HarveyMuir Wallace
Jul 23, 2009·Critical Care Medicine·Keith A MarillPatrick T Ellinor
May 10, 2020·Journal of Clinical Medicine·Régis GuieuGianfranco Parati
Jan 24, 2003·Prehospital Emergency Care : Official Journal of the National Association of EMS Physicians and the National Association of State EMS Directors·Corey M SlovisEdgardo J Rivera-Rivera
Mar 6, 2021·Journal of Arrhythmia·Anunay GuptaAmit Malviya
Oct 22, 2010·Circulation·Robert W NeumarLaurie J Morrison