PMID: 8594884Dec 1, 1995Paper

Adenosine inhibits arginine vasopressin-stimulated chloride secretion in a mouse IMCD cell line (mIMCD-K2)

The American Journal of Physiology
B MoyerB A Stanton

Abstract

Previously, we demonstrated that a mouse inner medullary collecting duct cell line (mIMCD-K2) secretes Cl- by an electrogenic mechanism via cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channels [N. L. Kizer, B. Lewis, and B. A. Stanton. Am. J. Physiol. 268 (Renal Fluid Electrolyte Physiol. 37): F347-F355, 1995; N. L. Kizer, D. Vandorpe, B. Lewis, B. Bunting, J. Russell, and B. A. Stanton. Am. J. Physiol. 268 (Renal Fluid Electrolyte Physiol. 37): F854-F861, 1995; D. Vandorpe, N. Kizer, F. Ciampolillo-Bates, B. Moyer, K. Karlson, W. B. Guggino, and B. A. Stanton. Am. J. Physiol. 269 (Cell Physiol. 38): C683-C689, 1995]. The objective of the present study was to determine whether adenosine, and adenosine A1 receptors (A1AR) specifically, regulate electrogenic Cl- secretion (IscCl) in mIMCD-K2 cells. Neither N6-cyclohexyladenosine (CHA), a specific A1AR agonist, nor 8-cyclopentyl-1,3-dipropylxanthine (DPCPX), a specific A1AR antagonist, altered basal, unstimulated IscCl in monolayers of mIMCD-K2 cells mounted in Ussing-type chambers. In contrast, DPCPX increased arginine vasopressin (AVP)-stimulated IscCl, an effect that was reversed by CHA. Adenosine deaminase (ADA), which oxidatively deaminates adenosine to ino...Continue Reading

Citations

Mar 25, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Sophie Moreau-MarquisBruce A Stanton
Oct 12, 2000·Anais Da Academia Brasileira De Ciências·M M MoralesA G Lopes
Jan 3, 2001·American Journal of Physiology. Renal Physiology·I RuberaP Poujeol
Jul 4, 2006·Physiological Reviews·Volker VallonHartmut Osswald
Nov 13, 2001·American Journal of Physiology. Renal Physiology·H S KangG A Quamme
Oct 21, 2005·American Journal of Physiology. Cell Physiology·Agnieszka Swiatecka-UrbanBruce A Stanton
Jul 29, 2008·Current Opinion in Nephrology and Hypertension·Francesca Di Sole

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