PMID: 8967391Apr 1, 1996Paper

Adenosine kinetics in canine coronary circulation

The American Journal of Physiology
K Kroll, D W Stepp

Abstract

Adenosine kinetics in the coronary circulation were investigated in anesthetized closed-chest dogs by analysis of multiple-indicator dilution experiments. During simultaneous intracoronary bolus injections of 125I-labeled albumin, [14C]sucrose, and [3H]adenosine, dilution curves were measured by automated sampling of coronary venous blood, using high-performance liquid chromatography and isotope detection techniques. Under control conditions, only 1% of the injected [3H]adenosine was detected in coronary venous samples, compared with the reference tracer, [14C]sucrose, and the peak of the adenosine dilution curve preceded those of the reference tracers by 2-4 s. Optimized model fits to the control adenosine curves required the combination of high ratios of the capillary endothelial cell membrane permeability-surface area product to flow (5.3) and endothelial cell consumption capacity to flow (23), in addition to a broad heterogeneity of flow. Dilution curves were measured under control conditions and during increased coronary flow (nitroglycerin), inhibition of the enzyme adenosine kinase (iodotubercidin), and blockade of membrane adenosine transport (dipyridamole). Reliability of the parameter estimates was confirmed using res...Continue Reading

Citations

Jan 25, 2000·American Journal of Physiology. Heart and Circulatory Physiology·J D TuneE O Feigl
Aug 5, 2000·Journal of Applied Physiology·K N RichmondE O Feigl
Dec 18, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·D WotheL Davis
Oct 29, 2000·Journal of Applied Physiology·M W GormanE O Feigl
Mar 23, 2002·Experimental Biology and Medicine·Johnathan D TuneEric O Feigl
Jun 29, 2004·Journal of Applied Physiology·Johnathan D TuneEric O Feigl
Oct 12, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Eric O Feigl
Feb 13, 2001·American Journal of Physiology. Heart and Circulatory Physiology·J D TuneE O Feigl

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