Adenosine methylation as a molecular imprint defining the fate of RNA

FEBS Letters
Philip Knuckles, Marc Bühler

Abstract

Multiple lines of evidence suggest the RNA modification N6 -methyladonsine (m6 A), which is installed in the nucleus cotranscriptionally and, thereafter, serves as a reversible chemical imprint that influences several steps of mRNA metabolism. This includes but is not limited to RNA folding, splicing, stability, transport and translation. In this Review we focus on the current view of the nuclear installation of m6 A as well as the molecular players involved, the so called m6 A writers. We also explore the effector proteins, or m6 A readers, that decode the imprint in different cellular contexts and compartments, and ultimately, the way the modification influences the lifecycle of an RNA molecule. The wide evolutionary conservation of m6 A and its critical role in physiology and disease warrants further studies into this burgeoning and exciting field.

References

Dec 15, 1979·Journal of Molecular Biology·S Chen-KiangJ E Darnell
Sep 1, 1990·Molecular and Cellular Biology·S M CarrollF M Rottman
Aug 14, 1980·Biochemical and Biophysical Research Communications·F HaradaS Nishimura
Jun 4, 2004·Human Molecular Genetics·Ilona RafalskaStefan Stamm
Nov 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Keiko HoriuchiTatsuhiko Kodama
Aug 8, 2009·Nature·Joseph M WattsKevin M Weeks
Feb 20, 2010·The Journal of Biological Chemistry·Zhaiyi ZhangStefan Stamm
Jul 5, 2011·Molecular Cell·Svetlana LebedevaNikolaus Rajewsky
Oct 18, 2011·Nature Chemical Biology·Guifang JiaChuan He
Mar 1, 2012·Nucleic Acids Research·Pradipta KunduWitold Filipowicz
May 12, 2012·Nature·Dan DominissiniGideon Rechavi
Jun 19, 2012·Nature Neuroscience·Philip KnucklesVerdon Taylor
Jul 17, 2012·Nature Structural & Molecular Biology·Sara MaciasJavier F Cáceres
Sep 3, 2013·Nature Structural & Molecular Biology·Sara R HerasJavier F Cáceres
Oct 9, 2013·The Journal of Biological Chemistry·Keiko HoriuchiTakao Hamakubo
Dec 10, 2013·Nature Chemical Biology·Jianzhao LiuChuan He
May 6, 2014·Molecular Cell·Gwendal DujardinAlberto R Kornblihtt
Sep 23, 2014·Nature Chemical Biology·Chao XuJinrong Min
Nov 13, 2014·Nucleic Acids Research·Dominik ThelerFrédéric H-T Allain
Jan 23, 2015·Journal of the American Chemical Society·Caroline RoostEric T Kool
Mar 25, 2015·Nature·Robert C SpitaleHoward Y Chang
Mar 25, 2015·Nature·Claudio R AlarcónSohail F Tavazoie
Jun 30, 2015·Nature Methods·Bastian LinderSamie R Jaffrey
Sep 1, 2015·Cell·Claudio R AlarcónSohail F Tavazoie
Sep 26, 2015·Genes & Development·Shengdong KeRobert B Darnell

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Citations

Sep 11, 2018·FEBS Letters·Mihaela Zavolan, André P Gerber
Oct 5, 2019·Nature Structural & Molecular Biology·Konstantinos TzelepisTony Kouzarides
Oct 16, 2019·BMC Plant Biology·Jagna Chmielowska-BąkJoanna Deckert
Jul 28, 2020·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Therese C KichukJosé L Avalos
Aug 12, 2018·International Journal of Molecular Sciences·Zaira Ianniello, Alessandro Fatica
Dec 6, 2018·Cell Research·Sebastian Krüttner, Pico Caroni
Aug 5, 2018·Histochemistry and Cell Biology·Irene MasielloMarco Biggiogera
Sep 17, 2020·Chembiochem : a European Journal of Chemical Biology·Anna M RydzikDoris Riether
Dec 24, 2018·Trends in Microbiology·Usama AshrafNadia Naffakh
Jun 20, 2021·Nature Communications·Praveen BawankarJean-Yves Roignant
Jun 30, 2021·The EMBO Journal·Kensuke NinomiyaTetsuro Hirose
May 14, 2020·Cell Reports·Gaia Di TimoteoIrene Bozzoni

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Methods Mentioned

BETA
immunoprecipitation
interaction studies
icSHAPE
CLIP
dissect
imaging techniques
nuclear translocation

Software Mentioned

icSHAPE
MACOM
METTL

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