Adenosine plasma level and A2A adenosine receptor expression: correlation with laboratory tests in patients with neurally mediated syncope

Heart
Jean-Claude DeharoRégis P Guieu

Abstract

The purpose of this study was to investigate the hypothesis that responses to the ATP test and head-up tilt test (HUT) may be correlated with different purinergic profiles. The ATP and HUT identify distinct subsets of patients with neurally mediated syncope (NMS). Adenosine and its A(2A) receptors (A(2A)R) may be implicated in the pathophysiology of NMS in patients with positive HUT. Nothing is known about the purinergic profile of patients with positive ATP. PATIENTS AND MEASURES: This prospective study includes a consecutive series of patients with suspected NMS. All patients underwent both HUT and ATP. Before testing, samples were collected for measurement of baseline adenosine plasma level (APL) and expression. A total of 46 patients (25 men and 21 women) with a mean age of 57±18 years were enrolled. The HUT test was positive in 27 patients and the ATP test in 20. Both tests were positive in 9 and negative in 8. High APL was associated with high probability of positive HUT while low APL was associated with high probability of positive ATP. Expression of A(2A)R was lower in patients with positive ATP than in those with positive HUT. These findings indicate that patients with NMS present different purinergic profiles and that...Continue Reading

Citations

Apr 19, 2013·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·F FranceschiR Guieu
Jun 12, 2014·Autonomic Neuroscience : Basic & Clinical·Monica Solbiati, Robert Stanley Sheldon
Jun 3, 2015·Pharmacology, Biochemistry, and Behavior·Brandon M Fritz, Stephen L Boehm
Dec 12, 2012·Cardiology Clinics·Angel MoyaNuria Rivas
Dec 23, 2015·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Michele BrignoleJean Claude Deharo
Jul 13, 2013·FEBS Open Bio·Laurent JacquinJean Ruf
Jul 15, 2015·Journal of the American College of Cardiology·Regis GuieuMichele Brignole
Aug 3, 2013·Heart·Reginald Liew
Jul 30, 2015·Canadian Journal of Physiology and Pharmacology·Yves JammesStéphane Delliaux
Jun 28, 2015·Cardiology Clinics·Michele BrignoleRegis Guieu
Jul 3, 2013·Journal of the American College of Cardiology·Jean-Claude DeharoMichele Brignole
Oct 8, 2014·Journal of Intensive Care Medicine·Jordan C RayNora Goldschlager
May 10, 2020·Journal of Clinical Medicine·Régis GuieuGianfranco Parati
May 26, 2020·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Michele BrignoleRegis Guieu
May 31, 2018·Herzschrittmachertherapie & Elektrophysiologie·Jean-Claude DeharoRégis Guieu
Mar 7, 2019·American Journal of Therapeutics·Cristian Podoleanu, Jean-Claude Deharo
Jan 8, 2020·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Masih TajdiniAli Bozorgi
Sep 30, 2020·Cardiovascular Research·Franck PaganelliRégis Guieu
Jul 25, 2021·International Journal of Molecular Sciences·Régis GuieuJean Ruf

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