Adenosine Receptor Activation in the "Trigger" Limb of Remote Pre-Conditioning Mediates Human Endothelial Conditioning and Release of Circulating Cardioprotective Factor(s)

JACC. Basic to Translational Science
Hussain ContractorRajesh K Kharbanda

Abstract

Remote ischemic pre-conditioning (rIPC) has emerged as a potential mechanism to reduce ischemia-reperfusion injury. Clinical data, however, have been mixed, and its physiological basis remains unclear, although it appears to involve release of circulating factor(s) and/or neural pathways. Here, the authors demonstrate that adenosine receptor activation is an important step in initiating human pre-conditioning; that pre-conditioning liberates circulating cardioprotective factor(s); and that exogenous adenosine infusion is able to recapitulate release of this factor. However, blockade of adenosine receptors in ischemic tissue does not block the protection afforded by pre-conditioning. These data have important implications for defining the physiology of human pre-conditioning and its translation to future clinical trials.

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Citations

Dec 9, 2016·Pflügers Archiv : European journal of physiology·Petra KleinbongardGerd Heusch
Oct 2, 2019·International Journal of Molecular Sciences·Youn Joung Cho, Won Ho Kim
Jan 8, 2021·Journal of Applied Physiology·Caitlin P JarrardSophie Lalande

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