Adenosine receptor agonists modulate visceral hyperalgesia in the rat.

Gut and Liver
Chong-Il SohnG F Gebhart


Adenosine is an endogenous modulator of nociception. Its role in visceral nociception, particularly in visceral hyperalgesia, has not been studied. The aim of this study was to determine the effects of adenosine receptor agonists in a model of visceral hyperalgesia. The visceromotor response (VMR) in rats to colorectal distension (CRD; 80 mmHg, 20 seconds) was quantified by electromyographic recordings from the abdominal musculature. Three hours after the intracolonic administration of zymosan (25 mg/mL, 1 mL), VMRs to CRD were measured before and after either subcutaneous or intrathecal administration of an adenosine receptor agonist. Subcutaneous injection of 5'-N-ethylcarboxyamidoadenosine (NECA; an A1 and A2 receptor agonist), R(-)-N6-(2-phenylisopropyl)-adenosine (R-PIA; a selective A1 receptor agonist), or CGS-21680 hydrochloride (a selective A2a receptor agonist) dose-dependently (10-100 mg/kg) attenuated the VMR to CRD, although hindlimb weakness occurred at the higher doses tested. Intrathecal administration of NECA or R-PIA dose-dependently (0.1-1.0 microg/kg) decreased the VMR, whereas CGS-21680 hydrochloride was ineffective over the same concentration range. Higher intrathecal doses of the A1/A2 receptor agonist NEC...Continue Reading


Jan 1, 1989·Neuroscience·J Sawynok, M I Sweeney
Jan 1, 1997·Acta Anaesthesiologica Scandinavica. Supplementum·A Sollevi
Jul 3, 1998·European Journal of Pharmacology·J Sawynok
Jul 29, 1998·Bioorganic & Medicinal Chemistry·S A Poulsen, R J Quinn
Nov 26, 1998·Japanese Journal of Pharmacology·M P Abbracchio, G Burnstock
May 29, 1999·Gastroenterology·S V Coutinho, G F Gebhart
Aug 6, 1999·British Journal of Anaesthesia·C P RaeJ Kinsella
May 9, 2006·Gastroenterology·David GrundyJackie D Wood
May 11, 2007·The American Journal of Gastroenterology·Sami R Achem

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