Adenosine Receptor-Mediated Developmental Loss of Spike Timing-Dependent Depression in the Hippocampus

Cerebral Cortex
Mikel Pérez-RodríguezA Rodríguez-Moreno

Abstract

Critical periods of synaptic plasticity facilitate the reordering and refining of neural connections during development, allowing the definitive synaptic circuits responsible for correct adult physiology to be established. Presynaptic spike timing-dependent long-term depression (t-LTD) exists in the hippocampus, which depends on the activation of NMDARs and that probably fulfills a role in synaptic refinement. This t-LTD is present until the third postnatal week in mice, disappearing in the fourth week of postnatal development. We were interested in the mechanisms underlying this maturation related loss of t-LTD and we found that at CA3-CA1 synapses, presynaptic NMDA receptors (pre-NMDARs) are tonically active between P13 and P21, mediating an increase in glutamate release during this critical period of plasticity. Conversely, at the end of this critical period (P22-P30) and coinciding with the loss of t-LTD, these pre-NMDARs are no longer tonically active. Using immunogold electron microscopy, we demonstrated the existence of pre-NMDARs at Schaffer collateral synaptic boutons, where a decrease in the number of pre-NMDARs during development coincides with the loss of both tonic pre-NMDAR activation and t-LTD. Interestingly, thi...Continue Reading

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Citations

Jun 4, 2019·Proceedings of the National Academy of Sciences of the United States of America·Iaroslav SavtchoukAndrea Volterra
Mar 16, 2019·Frontiers in Cellular Neuroscience·Pedro Mateos-Aparicio, Antonio Rodríguez-Moreno
Jun 16, 2019·Proceedings of the National Academy of Sciences of the United States of America·Isabel Pérez-Otaño, Antonio Rodríguez-Moreno
Sep 3, 2020·Nature Communications·Rafael Falcón-MoyaAntonio Rodríguez-Moreno
Jun 20, 2020·Molecular Psychiatry·Luis Enrique Arroyo-GarcíaGonzalo Flores
Aug 28, 2019·International Journal of Molecular Sciences·Rafael Falcón-MoyaAntonio Rodríguez-Moreno
Sep 29, 2020·Frontiers in Cell and Developmental Biology·Pedro Mateos-AparicioAntonio Rodríguez-Moreno
Nov 4, 2020·The Journal of Physiology·Hovy Ho-Wai WongP Jesper Sjöström
Apr 11, 2021·Neurochemical Research·José Antonio Noriega-Prieto, Alfonso Araque
May 11, 2021·Frontiers in Cellular Neuroscience·Emma Louise LouthMarco Capogna
Jul 6, 2021·Frontiers in Molecular Neuroscience·Yuniesky Andrade-Talavera, Antonio Rodríguez-Moreno
Jul 19, 2021·Neuropharmacology·Rafael Falcón-Moya, Antonio Rodríguez-Moreno
Aug 3, 2021·Trends in Neurosciences·Caitlin DurkeeAlfonso Araque
Jul 23, 2021·Journal of Neurochemistry·Rafael Falcón-MoyaAntonio Rodríguez-Moreno
Aug 8, 2021·Neuropharmacology·Jeffrey C WatkinsBruno G Frenguelli

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Methods Mentioned

BETA
electron microscopy

Software Mentioned

pCLAMP
Clampfit

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