Adenosine receptor mediated stimulation of ventilation in man

European Journal of Clinical Investigation
B JonzonR Brandt

Abstract

We wanted to examine how adenosine stimulates ventilation in man. Bolus doses of adenosine were given i.v. in an antebrachial vein in multiples of 2.65 mg. The minute ventilation was increased by adenosine 5.3 to 15.9 mg (median values) from control 12.6 +/- 1.9 l min-1 to 42.5 +/- 4.7 l min-1 in a dose-dependent manner. The adenosine receptor antagonist theophylline, 58.3 +/- 3.3 (mean +/- SEM) mumol l-1 plasma, inhibited the response by approximately 25%. Dipyridamole 10 mg, an adenosine uptake blocker, enhanced the effect of adenosine by approximately 60%. The ventilation was not affected by metoprolol, atropine, naloxone or cromolyn sodium but was attenuated by hyperventilation. The respiratory stimulation started before chest pain and cardiovascular effects such as AV-block were encountered. It is concluded that this respiratory stimulation shows characteristics of adenosine receptor mediated responses but the location of such adenosine receptors is uncertain. The findings are compatible with a stimulatory or facilitating effect of adenosine on afferent pathways.

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Apr 1, 1995·Journal of Clinical Pharmacology·G A RongenT Thien
Sep 6, 2014·Anesthesia Progress·Satoru SakuraiYuzuru Kaneko
Aug 16, 2008·Respiratory Physiology & Neurobiology·Gaspard MontandonAida Bairam
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Aug 5, 2000·The Annals of Pharmacotherapy·P S SheltonS E Krick
Jan 1, 1992·Journal of Gastroenterology and Hepatology·H Orrego, F J Carmichael

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