Adenosine receptor subtype-selective antagonists in inflammation and hyperalgesia

Naunyn-Schmiedeberg's Archives of Pharmacology
Andras Bilkei-GorzoAndreas Zimmer

Abstract

In this study, we examined the effects of systemic and local administration of the subtype-selective adenosine receptor antagonists PSB-36, PSB-1115, MSX-3, and PSB-10 on inflammation and inflammatory hyperalgesia. Pharmacological blockade of adenosine receptor subtypes after systemic application of antagonists generally led to a decreased edema formation after formalin injection and, with the exception of A(3) receptor antagonism, also after the carrageenan injection. The selective A(2B) receptor antagonist PSB-1115 showed a biphasic, dose-dependent effect in the carrageenan test, increasing edema formation at lower doses and reducing it at a high dose. A(1) and A(2B) antagonists diminished pain-related behaviors in the first phase of the formalin test, while the second, inflammatory phase was attenuated by A(2B) and A(3) antagonists. The A(2B) antagonist was particularly potent in reducing inflammatory pain dose-dependently reaching the maximum effect at a low dose of 3 mg/kg. Inflammatory hyperalgesia was totally eliminated by the A(2A) antagonist MSX-3 at a dose of 10 mg/kg. In contrast to the A(1) antagonist, the selective antagonists of A(2A), A(2B), and A(3) receptors were also active upon local administration. Our resul...Continue Reading

References

Jul 1, 1996·British Journal of Pharmacology·A K DixonT C Freeman
Oct 1, 1996·Trends in Pharmacological Sciences·E Ongini, B B Fredholm
Jul 3, 1998·European Journal of Pharmacology·J Sawynok
Jul 4, 1998·Trends in Pharmacological Sciences·K A Jacobson
May 13, 1999·Proceedings of the National Academy of Sciences of the United States of America·A ZimmerT I Bonner
May 26, 1999·Pharmacology, Biochemistry, and Behavior·E A KowalukM F Jarvis
Jan 5, 2000·European Journal of Pharmacology·J SawynokX J Liu
Nov 4, 2000·Expert Opinion on Investigational Drugs·E A Kowaluk, M F Jarvis
Mar 27, 2001·Annual Review of Pharmacology and Toxicology·J Linden
Aug 8, 2001·Japanese Journal of Pharmacology·V RamkumarZ Nie
Jan 1, 1996·Drug Development Research·I Feoktistov, I Biaggioni
Feb 7, 2003·Current Topics in Medicinal Chemistry·Christa E Müller
Jun 17, 2003·Journal of Neurochemistry·Susanna RosiGary L Wenk
Oct 18, 2003·The Journal of Pharmacology and Experimental Therapeutics·Osama M Abo-SalemChrista E Müller
Dec 31, 2003·Trends in Immunology·György Haskó, Bruce N Cronstein
Apr 24, 2004·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·M LivingstonM Ennis
Jun 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dmitriy LukashevMichail Sitkovsky
Jul 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hays W J YoungMichael R Blackburn
Jan 11, 2005·Current Topics in Medicinal Chemistry·Steve McGaraughtyRobert F Berman
Mar 17, 2005·Journal of Cell Science·Jean-Sébastien CadieuxMarc Pouliot

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Citations

Jun 4, 2010·American Journal of Physiology. Renal Physiology·Mattias CarlströmWilliam J Welch
Aug 4, 2011·Pharmacology & Therapeutics·Marie Therese ArmenteroRafael Franco
Jun 15, 2011·European Journal of Medicinal Chemistry·Anna DrabczyńskaKatarzyna Kieć-Kononowicz
Sep 29, 2009·Neurochemistry International·Hélio Vitoriano NobreGlauce Socorro de Barros Viana
Mar 26, 2015·Pain Management·Parisa Gazerani, Brian Edwin Cairns
Dec 28, 2010·Biochimica Et Biophysica Acta·Christa E Müller, Kenneth A Jacobson
Oct 16, 2013·Bioorganic & Medicinal Chemistry·Rhiannon ThomasGraham B Jones
Mar 5, 2015·Pharmacology, Biochemistry, and Behavior·Małgorzata ZygmuntJacek Sapa
Oct 27, 2016·Neuroscience·J Sawynok
Jan 5, 2013·Biochemistry·Dominik ThimmChrista E Müller
Feb 29, 2008·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Karl VollmannChrista E Müller
Nov 4, 2017·Journal of Clinical Medicine·Teita Asano, Mitsuko Takenaga
Sep 18, 2008·Analytical and Bioanalytical Chemistry·Sabine PlöttnerWolfram Föllmann
Mar 19, 2014·The Journal of Pharmacology and Experimental Therapeutics·Sonja HinzChrista E Müller
Apr 11, 2020·Journal of Biochemical and Molecular Toxicology·Osama Mohamed Abo-SalemWaleed Hassan Almalki
Aug 11, 2020·The Journal of Cell Biology·Antoine A KhalilPeter Friedl
Jul 25, 2019·Current Pharmaceutical Design·Balakumar ChandrasekaranNikhil Agrawal
Jul 1, 2020·Frontiers in Physiology·Luca SoattinThomas Jespersen
Dec 5, 2017·International Journal of Medicinal Chemistry·Gengyang YuanGraham B Jones
Mar 25, 2017·Brain Sciences·Nathan T FriedMichael L Oshinsky
Nov 22, 2020·International Journal of Molecular Sciences·Fabrizio VincenziKatia Varani
Jan 2, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Magdalena KotańskaKatarzyna Kieć-Kononowicz
Mar 6, 2019·Journal of Medicinal Chemistry·Jie JiangChrista E Müller

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