Adenosine receptors mediate both contractile and relaxant effects of adenosine in main pulmonary artery of guinea pigs

Naunyn-Schmiedeberg's Archives of Pharmacology
A J SzentmiklósiJ Z Szabó

Abstract

In guinea pig main pulmonary artery precontracted with noradrenaline, adenosine exerted an initial phasic contraction followed by a tonic contraction and a slow relaxation. After selective blockade by 1,3-dipropyl-8-cyclopentylxanthine (DPCPX: 10 nM) of A1 receptors, adenosine only elicited a rapid relaxation. This initial response was characterized by use of adenosine (AR) and its analogues N6-cyclopentyl-adenosine (CPA), R-N6-phenylisopropyladenosine (R-PIA), 2-chloroadenosine (CADO), 5'-N-ethyl-carboxamidoadenosine(NECA), N6-2-(4-aminophenyl) ethyl adenosine (APNEA) and 2-p-((carboxyethyl)-phenethylamino)-5'-carboxamidoadenosine (CGS 21 680). The order of potency of the adenosine analogues for purine-induced phasic contraction was CPA > R-PIA > NECA = APNEA > AR > CGS 21 680 suggesting the involvement of activation of A1 type adenosine receptors in the contraction phase. DPCPX antagonized the CPA-induced contraction with a pA2 = 9.27 +/- 0.26, but the Schild plot slope parameter was significantly lower than unity (0.58 +/- 0.09). In contrast, in electrically driven guinea pig atrial myocardium (a tissue reported to possess A1 receptors), the DPCPX-CPA antagonism was purely competitive (pA2 = 8.95 +/- 0.06; slope = 0.93 +/- 0...Continue Reading

References

May 6, 1975·Naunyn-Schmiedeberg's Archives of Pharmacology·H Osswald
Dec 11, 1975·The American Journal of Physiology·R M MentzerR M Berne
Aug 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·Q Y ZhouO Civelli
Mar 1, 1992·British Journal of Pharmacology·J NichollsI Kitchen
Jan 1, 1991·Experimental Lung Research·J E RoepkeR A Rhoades
Jul 1, 1990·Physiological Reviews·R A Olsson, J D Pearson
Nov 13, 1990·European Journal of Pharmacology·S M Stoggall, J S Shaw
Feb 1, 1989·British Journal of Pharmacology·N P WiklundL E Gustafsson
Aug 1, 1987·Naunyn-Schmiedeberg's Archives of Pharmacology·M J LohseR A Olsson
Oct 1, 1985·Journal of Medicinal Chemistry·W H MoosR F Bruns
Sep 1, 1985·Naunyn-Schmiedeberg's Archives of Pharmacology·U SchwabeM J Lohse
Nov 1, 1987·Acta Physiologica Scandinavica·N P WiklundL E Gustafsson
Apr 1, 1987·Naunyn-Schmiedeberg's Archives of Pharmacology·M FreissmuthW Schütz
Sep 7, 1987·Life Sciences·G GhaiM F Hopkins
Feb 1, 1987·British Journal of Pharmacology·T P Kenakin, N B Pike
Jul 1, 1972·The American Journal of Physiology·J SchraderR Rubio
Jan 1, 1983·British Journal of Pharmacology·M G Collis
Dec 9, 1983·European Journal of Pharmacology·M G Collis, C M Brown
Oct 15, 1981·European Journal of Pharmacology·S G GriffithG Burnstock
Feb 3, 1994·European Journal of Pharmacology·J R Fozard, J P Hannon
May 1, 1993·British Journal of Pharmacology·J R Fozard, A M Carruthers
Mar 1, 1959·British Journal of Pharmacology and Chemotherapy·O ARUNLAKSHANA, H O SCHILD
Jul 6, 1931·The Journal of Physiology·D W Bennet, A N Drury

❮ Previous
Next ❯

Citations

Sep 25, 2004·Journal of Cellular Physiology·R YaarKatya Ravid
Feb 1, 2003·European Journal of Pharmacology·Carmen DinizJorge Gonçalves
Dec 1, 2001·Pharmacology & Therapeutics·R Tabrizchi, S Bedi
May 23, 2002·Journal of the American College of Surgeons·David G LucasFrancis G Spinale
Mar 7, 2006·Nature Reviews. Drug Discovery·Kenneth A Jacobson, Zhan-Guo Gao
Oct 19, 2001·British Journal of Pharmacology·P NieriM C Breschi
Jun 17, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Brian J Koos
Jun 15, 2007·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Sule KalkanYesim Tuncok
Jun 24, 2008·Microscopy Research and Technique·Sandra LealCarmen Diniz
Oct 27, 2004·Experimental Eye Research·Mami HiraoTsunehiko Ikeda
Jul 11, 2006·Vascular Pharmacology·Tamsin L Jenner, Roselyn B Rose'Meyer
May 26, 2015·Autonomic Neuroscience : Basic & Clinical·Vera Ralevic, William R Dunn
Oct 20, 2005·Cephalalgia : an International Journal of Headache·U ArulmaniP R Saxena
Aug 14, 2012·Pharmacological Reviews·Geoffrey BurnstockJean-Pierre Timmermans
Dec 18, 2013·Pharmacological Reviews·Geoffrey Burnstock, Vera Ralevic
Mar 1, 1997·Journal of Applied Physiology·T S HakimE M Camporesi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.