Adenosine stress CMR perfusion imaging of the temporal evolution of perfusion defects in a porcine model of progressive obstructive coronary artery occlusion

NMR in Biomedicine
M Van HoutenM Salerno

Abstract

Adenosine stress CMR perfusion imaging can quantify absolute perfusion and myocardial perfusion reserve (MPR) in coronary artery disease (CAD) with higher spatial resolution than positron emission tomography, the only clinically available technique for quantitative myocardial perfusion imaging. While porcine models of CAD are excellent for studying perfusion abnormalities in chronic CAD, to date there are a limited number of studies that use quantitative perfusion for evaluation. Therefore, we developed an adenosine stress CMR protocol to evaluate the temporal evolution of perfusion defects in a porcine model of progressive obstructive CAD. 10 Yucatan minipigs underwent placement of an ameroid occluder around the left circumflex artery (LCX) to induce a progressive chronic coronary obstruction. Four animals underwent a hemodynamic dose range experiment to determine the adenosine dose inducing maximal hyperemia. Each animal had a CMR examination, including stress/rest spiral quantitative perfusion imaging at baseline and 1, 3, and 6 weeks. Late gadolinium enhancement images determined the presence of myocardial infarction, if any existed. Pixelwise quantitative perfusion maps were generated using Fermi deconvolution. The results...Continue Reading

References

Dec 1, 1992·Circulation Research·F C WhiteC M Bloor
Jun 23, 1994·The New England Journal of Medicine·N G UrenP G Camici
Mar 27, 2003·Journal of Cardiovascular Pharmacology·Jinsheng LiKeith A Robinson
Jun 25, 2003·Circulation·William F FearonAlan C Yeung
Jan 9, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Dallit MannheimAmir Lerman
Jan 20, 2009·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Daniel S BermanGuido Germano
Oct 8, 2009·Circulation. Cardiovascular Imaging·Michael Salerno, George A Beller
Mar 12, 2010·The New England Journal of Medicine·Manesh R PatelPamela S Douglas
Jul 29, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Michael Lustig, John M Pauly
Sep 22, 2010·The Journal of Pharmacology and Experimental Therapeutics·Xin LongMichael Sturek
May 19, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Michael SalernoCraig H Meyer
Nov 21, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Nilesh R GhugreGraham A Wright
May 15, 2013·Imaging in Medicine·Ryo NakazatoPiotr Slomka
Jun 21, 2014·Seminars in Nuclear Medicine·Thomas H SchindlerVasken Dilsizian
Aug 8, 2015·Clinical and Translational Imaging : Reviews in Nuclear Medicine and Molecular Imaging·Piotr SlomkaGuido Germano
Feb 26, 2016·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Milena J HenzlovaHein J Verberne
Jul 10, 2016·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Vasken DilsizianMark I Travin
Feb 12, 2017·The International Journal of Cardiovascular Imaging·Roel S DriessenPaul Knaapen
Oct 7, 2017·JACC. Cardiovascular Imaging·Amit R Patel, Christopher M Kramer
Feb 24, 2018·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Benjamin ZorachMichael Salerno
Mar 9, 2018·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Allison D TaAndrew E Arai
Jul 3, 2018·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Hung P DoKrishna S Nayak

❮ Previous
Next ❯

Citations

Apr 9, 2021·NMR in Biomedicine·Caroline M ColbertKim-Lien Nguyen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Remodeling

Cardiac remodeling in response to a myocardial infarction is characterized by progressive ventricular dilatation, cardiac hypertrophy, fibrosis, and deterioration of cardiac performance. Discover the latest research on Cardiac Remodeling here.