PMID: 18709016Aug 19, 2008Paper

Adenosine stress protocols for nuclear cardiology imaging

Prilozi
Branislav BaskotMiodrag Pavlović

Abstract

The treadmill test combined with myocardial perfusion imaging (MPI) is a commonly used technique in the assessment of coronary artery disease (CAD). However, there is a group of patients who may not be able to undergo the treadmill test. Pharmacologic stress testing is increasingly utilized for stress perfusion imaging and currently accounts for nearly 40% of all nuclear stress testing [8]. The aim of this study was the introduction of adenosine stress protocols in our nuclear laboratory, and the following, recording and comparing of the frequency and severity of side-effects. We performed two kinds of adenosine stress protocols on 186 patients who underwent MPI with radiotracer 99mTc-sestamibi: 1st: 47 patients underwent AdenoSCAN abbreviated protocol IV. adenosin 140microg/kg/min for 3 minutes; 2nd: AdenoEX combined with low level 50W bicycle exercise in 139 patients. We followed and compared side-effects (minor and major events) between AdenoSCAN and AdenoEX protocol, and established an adequate time for imaging of both protocols. Compared with AdenoSCAN, AdenoEX protocol was tolerated by all patients; it reduced all side-effects and improved image quality. Using AdenoEX protocol we found that the heart-to-liver ratio was si...Continue Reading

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