Adenosine triphosphate citrate lyase mediates hypocitraturia in rats

The Journal of Clinical Investigation
J Z MelnickR J Alpern

Abstract

Chronic metabolic acidosis increases proximal tubular citrate uptake and metabolism. The present study addressed the effect of chronic metabolic acidosis on a cytosolic enzyme of citrate metabolism, ATP citrate lyase. Chronic metabolic acidosis caused hypocitraturia in rats and increased renal cortical ATP citrate lyase activity by 67% after 7 d. Renal cortical ATP citrate lyase protein abundance increased by 29% after 3 d and by 141% after 7 d of acid diet. No significant change in mRNA abundance could be detected. Hypokalemia, which causes only intracellular acidosis, caused hypocitraturia and increased renal cortical ATP citrate lyase activity by 28%. Conversely, the hypercitraturia of chronic alkali feeding was associated with no change in ATP citrate lyase activity. Inhibition of ATP citrate lyase with the competitive inhibitor, 4S-hydroxycitrate, significantly abated hypocitraturia and increased urinary citrate excretion fourfold in chronic metabolic acidosis and threefold in K+-depletion. In summary, the hypocitraturia of chronic metabolic acidosis is associated with an increase in ATP citrate lyase activity and protein abundance, and is partly reversed by inhibition of this enzyme. These results suggest an important rol...Continue Reading

References

Jul 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·I KippenE M Wright
Nov 1, 1991·The Journal of Clinical Investigation·O W MoeR J Alpern
Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J GeibelW F Boron
Oct 1, 1990·Kidney International·L L Hamm
Jan 1, 1988·The Journal of Clinical Endocrinology and Metabolism·N A BreslauC Y Pak
Jun 1, 1987·Kidney International·R E HernandezA Sebastian
Nov 1, 1987·The Journal of Clinical Endocrinology and Metabolism·K SakhaeeC Y Pak
Sep 21, 1973·European Journal of Biochemistry·S Cheema-DhadliC C Leznoff
Feb 1, 1969·The Journal of Clinical Investigation·G A Alleyne, G H Scullard
Mar 1, 1969·Archives of Biochemistry and Biophysics·G L Cottam, P A Srere
Jan 1, 1983·Urology·M J NicarC Y Pak
Jan 22, 1982·Biochimica Et Biophysica Acta·S H WrightE M Wright
Sep 18, 1980·The New England Journal of Medicine·D RudmanM H Kutner
Sep 26, 1953·Lancet·C M OTTLEY

❮ Previous
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Citations

Oct 9, 2002·Clinica Chimica Acta; International Journal of Clinical Chemistry·Piyaratana TosukhowongPote Sriboonlue
Feb 20, 2003·Magnetic Resonance Imaging·Eimorn MairiangPote Sriboonlue
Nov 18, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kazuki AkiraTakao Hashimoto
Mar 18, 2000·Kidney International·J Z MelnickM Baum
Jul 28, 2001·Kidney International·H K ZajicekM Levi
Aug 8, 2002·Kidney International·Khashayar SakhaeeCharles Y C Pak
Nov 25, 2003·Kidney International·Jamshid AmanzadehMoshe Levi
Dec 10, 2003·The Journal of Biological Chemistry·Anne P BeigneuxStephen G Young
Jun 16, 2006·Current Opinion in Nephrology and Hypertension·Orson W Moe, Patricia A Preisig
Dec 1, 2004·Kidney International·Tiziana MeschiLoris Borghi
Apr 1, 1999·Annual Review of Physiology·A M Pajor
Aug 21, 2009·American Journal of Physiology. Renal Physiology·I Alexandru BobulescuOrson W Moe
Jun 23, 1998·Lancet·C Y Pak
Sep 20, 2007·Expert Opinion on Drug Safety·Damaris VegaKhashayar Sakhaee
Jul 2, 1998·Kidney International·J Z MelnickR J Alpern
May 12, 2012·Biochemical and Biophysical Research Communications·Melanie ChypreKarine Smans
Jun 3, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·P TosukhowongV Sitprija
Oct 31, 2006·Seminars in Nephrology·I Alexandru Bobulescu, Orson W Moe
Apr 25, 2006·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Eric N TaylorGary C Curhan
Jun 24, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Jason SheyOrson W Moe
Sep 26, 2006·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Brian J WelchKhashayar Sakhaee
Jan 4, 2007·International Journal of Urology : Official Journal of the Japanese Urological Association·Naohiko OkamotoTadaichi Kitamura
Dec 12, 2002·Endocrinology and Metabolism Clinics of North America·L Lee Hamm, Kathleen S Hering-Smith
Nov 30, 2013·Biochimica Et Biophysica Acta·Beatriz Sánchez-SolanaRakesh Kumar
Oct 30, 2001·Clinical Pediatrics·K S Roth, J C Chan
Aug 8, 1998·The Journal of Biological Chemistry·X Z ChenM A Hediger
Apr 25, 2000·Hypertension·M E UllianW R Fitzgibbon
Mar 1, 2005·International Journal of Urology : Official Journal of the Japanese Urological Association·Piyaratana TosukhowongPote Sriboonlue
Feb 20, 2004·American Journal of Physiology. Cell Physiology·Seiji ArugaRobert J Alpern
Apr 14, 2006·The British Journal of Nutrition·Agnès NarcyChristian Rémésy
Aug 24, 2005·The British Journal of Nutrition·Houda SabbohChristian Demigné
Mar 28, 2019·Urolithiasis·Doyoung KimJohn R Asplin
Mar 11, 2000·American Journal of Physiology. Renal Physiology·K S Hering-SmithL L Hamm
Jan 5, 2002·Journal of Agricultural and Food Chemistry·B S JenaK K Sakariah

❮ Previous
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