Adenosine triphosphate stress myocardial perfusion imaging for risk stratification of patients aged 70 years and older with suspected coronary artery disease

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
Zhiming YaoWenjie Zhang

Abstract

We investigated the cardiac risk stratification value of adenosine triphosphate stress myocardial perfusion imaging (ATP-MPI) in patients aged 70 years and older with suspected coronary artery disease (CAD). We identified a series of 415 consecutive patients aged 70 years and older with suspected CAD, who had undergone ATP-MPI with 99mTc-MIBI. The presence of a fixed and/or reversible perfusion defect was considered as an abnormal MPI. Follow-up was available in 399 patients (96.1%) over 3.45 ± 1.71 years after excluding 16 patients who underwent early coronary revascularization <60 days after MPI. The major adverse cardiac events (MACE), including cardiac death, nonfatal infarction, and late coronary revascularization, were recorded. One hundred twenty-five (31.3%) patients had abnormal MPI and the remaining had normal MPI. A multivariable analysis using Cox regression demonstrated that abnormal MPI was independently associated with MACE (hazard ratio 19.50 and 95% confidence interval 5.91-64.31, P value .000). The patients with SSS > 8 had significantly higher cumulative MACE rate than patients with SSS ≤ 8 had (37.8% vs 5.2%, respectively, P < .001). The Kaplan-Meier cumulative MACE-free survival in patients with abnormal MP...Continue Reading

References

Dec 19, 2006·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Milena J HenzlovaUNKNOWN Quality Assurance Committee of the American Society of Nuclear Cardiology
Dec 25, 2009·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Pasquale Perrone-FilardiMassimo Chiariello
Jul 30, 2011·Science·Xizhe Peng
Nov 11, 2011·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Sanjeev U NairGary V Heller
Jan 1, 2014·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Alan RozanskiDaniel S Berman

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Citations

Feb 3, 2016·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Rayan Saab, Fadi G Hage
Jul 18, 2018·Circulation. Cardiovascular Imaging·Randall C Thompson, Krishna K Patel
Jul 18, 2018·Circulation. Cardiovascular Imaging·Fernanda ErthalBenjamin J W Chow
Apr 18, 2018·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Fadi G Hage, Wael A AlJaroudi
Jul 28, 2016·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Atif Alzahrani, Terrence D Ruddy
Apr 28, 2017·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Athanasios KatsikisMaria Koutelou
Jun 25, 2021·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Ming-Yen NgKai-Hang Yiu

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