Adenosine(5') oligophospho-(5') guanosines and guanosine(5') oligophospho-(5') guanosines in human platelets

The Journal of Clinical Investigation
H SchluterW Zidek

Abstract

We isolated and identified nucleoside(5') oligophospho-(5') nucleosides containing adenosine and guanosine (ApnG; n = 3-6) as well as diguanosine polyphosphates (GpnG; n = 3-6) in human platelets. For identification, UV spectrometry, matrix-assisted laser desorption/ionization, postsource decay matrix-assisted laser desorption/ionization mass spectrometry, and enzymatic cleavage experiments were used. The adenosine(5') oligophospho-(5') guanosines act as vasoconstrictors and growth factors. The diguanosine polyphosphates are potent modulators of growth in vascular smooth muscle cells, but do not affect vascular tone.

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Citations

Mar 31, 2005·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·V JankowskiJ Jankowski
Apr 25, 2003·Biochemical and Biophysical Research Communications·J JankowskiH Schlüter
Jul 30, 2002·European Journal of Pharmacology·Markus van der GietMartin Tepel
Sep 29, 2000·Pharmacology & Therapeutics·A G McLennan
Dec 30, 1998·Journal of Chromatography. B, Biomedical Sciences and Applications·J JankowskiH Schlüter
Oct 24, 2002·European Journal of Biochemistry·María A Günther SilleroAntonio Sillero
Jul 9, 2003·European Journal of Biochemistry·Petra VollmayerHerbert Zimmermann
Mar 2, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Eva SchepersRaymond Vanholder
Oct 6, 2007·Current Opinion in Rheumatology·Arnold E Postlethwaite, Thomas M Chiang
Jul 1, 2009·British Journal of Pharmacology·Vera JankowskiJoachim Jankowski
Jun 21, 2005·Biochemical and Biophysical Research Communications·Qing-Chuan ZhengChia-Chung Sun
Sep 23, 1998·FEBS Letters·O MadridM A Günther Sillero
May 10, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Joachim JankowskiHartmut Schlüter
Jun 3, 2000·Journal of Cardiovascular Pharmacology·N ZimmermannE Gams
Aug 14, 1999·The Journal of Biological Chemistry·J JankowskiH Schlüter
Jun 19, 2004·Platelets·Martyn P Mahaut-SmithRichard J Evans
Mar 30, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J LuoH Schlüter
Jan 9, 2004·The Journal of Pharmacology and Experimental Therapeutics·R Gómez-VillafuertesM T Miras-Portugal
Apr 7, 1999·Archives of Biochemistry and Biophysics·S A CampbellR H Hilderman

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