Adenosinergic signaling in epilepsy

Neuropharmacology
Detlev Boison

Abstract

Despite the introduction of at least 20 new antiepileptic drugs (AEDs) into clinical practice over the past decades, about one third of all epilepsies remain refractory to conventional forms of treatment. In addition, currently used AEDs have been developed to suppress neuronal hyperexcitability, but not necessarily to address pathogenic mechanisms involved in epilepsy development or progression (epileptogenesis). For those reasons endogenous seizure control mechanisms of the brain may provide alternative therapeutic opportunities. Adenosine is a well characterized endogenous anticonvulsant and seizure terminator of the brain. Several lines of evidence suggest that endogenous adenosine-mediated seizure control mechanisms fail in chronic epilepsy, whereas therapeutic adenosine augmentation effectively prevents epileptic seizures, even those that are refractory to conventional AEDs. New findings demonstrate that dysregulation of adenosinergic mechanisms are intricately involved in the development of epilepsy and its comorbidities, whereas adenosine-associated epigenetic mechanisms may play a role in epileptogenesis. The first goal of this review is to discuss how maladaptive changes of adenosinergic mechanisms contribute to the e...Continue Reading

References

Nov 1, 1992·Annals of Neurology·M J During, D D Spencer
May 1, 1991·Annals of Neurology·M Dragunow
Sep 1, 1989·Trends in Neurosciences·G L CantoniV Andreoli
Apr 1, 1986·British Journal of Pharmacology·B Ault, C M Wang
Sep 1, 1985·Epilepsia·M DragunowR Laverty
Jan 1, 1984·Annals of Neurology·O Z SellingerT E Wilens
Dec 1, 1994·Molecular Carcinogenesis·J L Counts, J I Goodman
Dec 29, 1998·European Journal of Pharmacology·G B Kaplan, T S Coyle
May 20, 1999·Journal of Neuropathology and Experimental Neurology·A A LieS W Schoen
Sep 15, 1999·Anesthesiology·A ChiariJ C Eisenach
Apr 13, 2000·The International Journal of Biochemistry & Cell Biology·S C Lu
Nov 4, 2000·Expert Opinion on Investigational Drugs·E A Kowaluk, M F Jarvis
Jun 19, 2001·Proceedings of the National Academy of Sciences of the United States of America·A HuberD Boison
May 9, 2002·Proceedings of the National Academy of Sciences of the United States of America·Detlev BoisonHanns Mohler
Jun 28, 2003·Brain Research. Molecular Brain Research·Alessandra Nejar BrunoJoão José Freitas Sarkis
Aug 20, 2003·The European Journal of Neuroscience·Nelson RebolaRodrigo A Cunha
Sep 27, 2003·Epilepsia·Lauren C Frey
Oct 4, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Yasuhisa FuruichiTakehiko Yanagihara
Jan 23, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nicolette GouderDetlev Boison
Mar 9, 2004·Brain Research. Brain Research Reviews·Karen E Nilsen, Hannah R Cock
Sep 10, 2004·Acta Neurologica Scandinavica·A GaitatzisJ W Sander
Oct 19, 2004·Neuroscience Letters·Denise E FedeleDetlev Boison
Oct 19, 2004·Lancet Neurology·Christian E ElgerMartin Kurthen
Dec 2, 2004·Epilepsia·Athanasios GaitatzisJosemir W Sander
Jan 6, 2005·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Detlev Boison
Jan 11, 2005·Current Topics in Medicinal Chemistry·Steve McGaraughtyRobert F Berman
Apr 12, 2005·Annual Review of Pharmacology and Toxicology·Bertil B FredholmJean-Marie Vaugeois
Aug 24, 2005·Nature Medicine·Guo-Feng TianMaiken Nedergaard
Aug 27, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Patrick M KochanekEdwin K Jackson

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Citations

Nov 10, 2015·Neuropharmacology·Tobias EngelDavid C Henshall
Jan 19, 2016·Neuropharmacology·Peter IllesBeata Sperlagh
Jun 23, 2016·Journal of Neurochemistry·Katarzyna LepetaConstanze Seidenbecher
Nov 24, 2016·Neurochemical Research·Kelly L DrewSarah A Rice
Oct 26, 2016·Journal of Neurochemistry·Diogo M RomboAna M Sebastião
May 5, 2017·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Rebecca M HauserFarah D Lubin
Apr 21, 2017·The Journal of Comparative Neurology·Paul S BuckmasterXiling Wen
May 17, 2017·Epilepsy & Behavior : E&B·Norberto Garcia-CairascoJosé A Cortes de Oliveira
Mar 10, 2018·International Journal of Molecular Sciences·Marcella CamiciMaria Grazia Tozzi
May 4, 2018·Nature Reviews. Disease Primers·Orrin DevinskyPiero Perucca
Jun 19, 2018·PloS One·Manuel SoliñoJuan José López-Costa
Jul 20, 2018·Journal of Neuroscience Research·Tore EidHitten P Zaveri
Feb 23, 2019·Nature Reviews. Neuroscience·Dipan C PatelHarald Sontheimer
Jul 31, 2019·Journal of Neurochemistry·Dietrich van CalkerTsvetan Serchov
Feb 25, 2018·Pharmacological Reports : PR·Krzysztof ŁukawskiStanisław J Czuczwar
Mar 23, 2018·Frontiers in Pharmacology·Mariana AlvesTobias Engel
Aug 31, 2018·Journal of Immunology Research·Margarete Dulce BagatiniFabiano Barbosa Carvalho
Mar 14, 2019·ASN Neuro·Eliana ScemesJana Velíšková
Jun 18, 2020·Nature Reviews. Neurology·Gary P Brennan, David C Henshall
Jun 23, 2020·Journal of Caffeine and Adenosine Research·Fabio C TescarolloDetlev Boison
Jul 10, 2019·Current Topics in Medicinal Chemistry·Jindian LiKai Chen
Nov 11, 2019·Glia·Ljiljana NikolicEtienne Audinat
Jun 16, 2016·Journal of Neuroscience Research·François Rassendren, Etienne Audinat
Aug 21, 2018·Frontiers in Neuroscience·Lucrezia CellaiVictoria Gomez-Murcia
Oct 19, 2019·Cancers·Simone de LeveVerena Jendrossek
Aug 10, 2017·Journal of Neuropathology and Experimental Neurology·Guoming LuanTianfu Li
Nov 30, 2019·Oxidative Medicine and Cellular Longevity·Yan LiuYunlong Zhang
Nov 18, 2018·International Journal of Molecular Sciences·Mercedes Garcia-GilMaria Grazia Tozzi
Jan 9, 2019·Frontiers in Neurology·Benton S PurnellGordon F Buchanan
Jan 23, 2018·Frontiers in Pharmacology·Amber KerkhofsHuibert D Mansvelder
Jun 29, 2018·Epilepsy Currents·Devin K Binder
Oct 28, 2020·Neurochemical Research·Emilia Rodrigues AlmeidaAnna Maria Siebel
Dec 2, 2020·Life Sciences·Enes AkyuzYam Nath Paudel

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