Adenosinergic system is involved in development of diazepam tolerance in mice

Pharmacology, Biochemistry, and Behavior
Joanna ListosSylwia Fidecka

Abstract

In the present study the effect of adenosinergic system on the development of diazepam tolerance to motor disturbances in mice was investigated. Diazepam tolerance was obtained by administration of diazepam at a dose of 5.0 mg/kg, s.c. for ten consecutive days. On the 1st and the 10th day of the experiment motor impairments were measured in two behavioural tests: rota-rod and chimney test. We showed that acute diazepam injection produced significant motor impairments in mice and that effect was decreased by repeated diazepam treatment, confirming the development of tolerance to the motor impairing effect of diazepam. We demonstrated that adenosine A(1) and/or A(2A) receptor agonists: CPA (0.025 and 0.05 mg/kg, i.p.), CGS 21680 (0.1 and 0.2 mg/kg, i.p.), NECA (0.005 and 0.01 mg/kg, i.p.) pretreatment with diazepam were able to attenuate the development of diazepam tolerance and adenosine receptor antagonists: DPCPX (1.0 and 3.0 mg/kg, i.p.), DMPX (3.0 and 6.0 mg/kg, i.p.) and caffeine (10.0 and 20.0mg/kg, i.p.) induced the opposite effect. The most apparent effects were obtained by non-selective agonist (NECA) and antagonist (caffeine) of adenosine receptors. We conclude that adenosinergic system plays an important role in mecha...Continue Reading

References

Jan 1, 1991·General Pharmacology·E Contreras, A Germany
Jun 1, 1988·Pharmacology, Biochemistry, and Behavior·M HawkinsM Radulovacki
Dec 25, 1982·Lancet·S B ArvidssonD Niemand
Jan 1, 1981·General Pharmacology·J W PhillisA S Bender
Sep 19, 1994·Brain Research·G B KaplanM T Sears
Apr 1, 1994·Pharmacology, Biochemistry, and Behavior·S E File, C Fernandes
Jul 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·K G Steppuhn, L Turski
Dec 12, 1995·European Journal of Pharmacology·P PopoliG Ricciarello
Aug 1, 1997·Neurochemical Research·M Pérez de la MoraK Fuxe
Jul 31, 1998·Progress in Neuro-psychopharmacology & Biological Psychiatry·V S Barwick, M S Dar
Dec 2, 1999·Japanese Journal of Pharmacology·M TsudaT Suzuki
Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·E IzzoE Costa
Apr 3, 2001·Annual Review of Neuroscience·T V Dunwiddie, S A Masino
Nov 16, 2001·Neuron·A B MacDermott
Jan 29, 2002·Current Pharmaceutical Design·A N Bateson
Feb 7, 2003·Current Topics in Medicinal Chemistry·Arvinder K DhallaLuiz Belardinelli
May 3, 2003·Pharmacology & Therapeutics·C Allison, J A Pratt
Mar 1, 1957·Journal of the American Pharmaceutical Association·N W DUNHAM, T S MIYA
Nov 26, 2003·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Giovanni BiggioPaolo Follesa
Dec 1, 2004·Basic & Clinical Pharmacology & Toxicology·Laura ConnoleMark Maginn
Jan 22, 2005·Current Opinion in Pharmacology·Keith A Wafford
Oct 18, 2005·European Journal of Pharmacology·Joanna ListosSylwia Fidecka
Feb 17, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Francisco CiruelaRafael Franco
Jun 24, 2006·Alcoholism, Clinical and Experimental Research·Salim Al-Rejaie, M Saeed Dar
Oct 24, 2006·Cellular and Molecular Life Sciences : CMLS·F CiruelaR Franco
Jul 25, 2007·Progress in Neurobiology·S N SchiffmannS Ferré
Feb 26, 2008·Pharmacology, Biochemistry, and Behavior·Stephanie C Licata, James K Rowlett
Apr 12, 2008·Purinergic Signalling·Kathrin Sichardt, Karen Nieber
May 10, 2008·European Journal of Pharmacology·Joanna ListosSylwia Fidecka

❮ Previous
Next ❯

Citations

Jan 3, 2016·Pharmacology, Biochemistry, and Behavior·Sylwia TalarekSylwia Fidecka
Nov 11, 2011·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Ozgür Devrim CanBetül Demirci

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.