Adenosine's role in hypercapnia-evoked cerebral vasodilation in the rat

Neuroscience Letters
J W PhillisM H O'Regan

Abstract

Carbon dioxide induces a rapid dilation of cerebral arterioles, enabling local blood flow to match increasing metabolic requirements of tissue. Amongst the vasodilatory substances released by cortical tissue in response to CO2 are adenosine and nitric oxide. Here we report that selective adenosine A(2A) receptor antagonists, applied topically using a rat cortical window technique, significantly depressed the CO2-evoked increase in arteriolar diameter, measured using video microscopy, as well as attenuating the CO2 and pH reactivity of the cortical arterioles. Two non-selective inhibitors of nitric oxide synthase also significantly depressed the hypercapnia-evoked increase in arteriolar diameter.

References

May 1, 1977·Stroke; a Journal of Cerebral Circulation·H A KontosJ L Patterson
Jan 1, 1987·General Pharmacology·J W Phillis, R E DeLong
Sep 13, 2003·European Journal of Pharmacology·John W Phillis, Michael H O'Regan

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Citations

Apr 19, 2005·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Andreas KochH Rieckert
Jan 23, 2010·Journal of Applied Physiology·Daniel K MulkeyOrsolya Kréneisz
Nov 26, 2013·Journal of Neurosurgery·Hai-Ying ShenDetlev Boison
Apr 15, 2005·Neurological Research·Michael O'Regan
Apr 15, 2005·Neurological Research·John W Phillis
Jul 22, 2018·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Mackenzie E CharterCoral L Murrant
Dec 18, 2013·Pharmacological Reviews·Geoffrey Burnstock, Vera Ralevic
Mar 22, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Nadine BrewFlora Y Wong
Mar 19, 2009·Pharmacological Reviews·Noboru TodaTomio Okamura
Aug 1, 2012·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Adam InstitorisDavid W Busija
Aug 30, 2014·Physiological Reports·Chukwuma C NnoromCharles W Leffler

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