Adenosquamous carcinoma of hypopharynx with intestinal-phenotype

Head and Neck Pathology
Marco A O MagalhaesBayardo Perez-Ordoñez

Abstract

Adenosquamous carcinomas of the head and neck (ADSCs) are rare locally aggressive malignancies characterized by the presence of two distinctive components, a squamous cell carcinoma and an adenocarcinoma. The immunophenotype of the glandular component of ADSCs has only been rarely studied but has been reported as being positive for keratin 7 (CK7) and carcinoembryonic antigen (CEA) and negative for keratin 20 (CK20). Herein, we report a case of an ADSCs of the hypopharynx composed of a superficial squamous cell carcinoma and an adenocarcinoma with an intestinal phenotype. The patient was a 62 year-old male with a T2 N0 M0 squamous cell carcinoma (SCC) of uvula and palate and a T1 N0 M0 of right hypopharynx. The ADSCs of the hypopharynx was composed of a minimally invasive SCC and an adenocarcinoma with tubulo-glandular and cribriform architecture. The neoplastic glands were positive for CK7, CK20, CDX2, CEA and Villin. The patient underwent radiotherapy to both tumors and remains well with no evidence of recurrent disease 19 months after treatment. To the best of our knowledge, this is the first report of an ADSCs of the head and neck with an intestinal phenotype in its glandular component.

References

Nov 1, 1990·The Journal of Laryngology and Otology·J I Lopez, A Perez
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Feb 10, 2006·The Annals of Otology, Rhinology, and Laryngology·Vicente A RestoDerrick T Lin
Sep 28, 2010·Critical Reviews in Oncology/hematology·Alessandro FranchiMarco Santucci
Sep 29, 2011·Head and Neck Pathology·Denisa SlovaBruce Wenig
Jun 14, 2012·Histopathology·Felipe Paiva FonsecaAlan Roger Santos-Silva
Jul 16, 2013·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Ulrike SchickMahmut Ozsahin

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Citations

Jul 14, 2018·Clinical Nuclear Medicine·Yujing HuYanzhu Bian
May 8, 2020·The American Journal of Dermatopathology·Husain AlomranBrigitte Balme

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