Adenosquamous carcinoma of the lung

OncoTargets and Therapy
Chenghui Li, Hongyang Lu

Abstract

Adenosquamous carcinoma of the lung (ASC), a relatively rare subtype of non-small-cell lung cancer, is defined as a malignancy containing components of lung adenocarcinoma (ADC) and lung squamous cell carcinoma (SCC). Although ASC has biological characteristics of ADC and SCC, it is not by any means a simple hybrid of two components above. It is extremely difficult to diagnose preoperatively; pathology of surgically resected gross specimen is the most effective means for adequate diagnosis of ASC. Platinum-based postoperative adjuvant chemotherapy for at least four cycles can significantly improve the survival in stage III patients with ASC. Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) such as erlotinib and gefitinib can be the effective therapeutic strategies for advanced EGFR-mutant ASC. The studies of crizotinib in the treatment of patients with ASC are very limited. Immune checkpoint blockade therapy may be a potential treatment choice for ASC patients.

Citations

Dec 12, 2018·Journal of Molecular Endocrinology·Afreen Idris ShariffLeonor Corsino
Jun 24, 2020·Cancers·Coral García-FernándezSalvador Borrós
Apr 15, 2020·Cancers·Abdulaziz B Hamid, Ruben C Petreaca
Nov 3, 2020·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Arthur KrauseLukas Bubendorf
Feb 14, 2021·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Cheng XuZhigang Zhuang
Apr 23, 2019·Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC·Sarah GlazeMáire A Duggan
Mar 11, 2020·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G LinC Huang
Jul 6, 2021·World Journal of Clinical Cases·Cai-Bao Jin, Ling Yang
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Methods Mentioned

BETA
surgical resection
biopsy
laser capture microdissection
xenograft
xenografts
PCR

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