Adenoviral vector type 26 encoding Zika virus (ZIKV) M-Env antigen induces humoral and cellular immune responses and protects mice and nonhuman primates against ZIKV challenge

PloS One
Freek CoxRoland Zahn

Abstract

In 2015, there was a large outbreak of Zika virus (ZIKV) in Brazil. Despite its relatively mild impact on healthy adults, ZIKV infection during pregnancy has been associated with severe birth defects. Currently, there is no ZIKV vaccine available, but several vaccine candidates based on the ZIKV membrane (M) and envelope (Env) structural proteins showed promising results in preclinical and clinical studies. Here, the immunogenicity and protective efficacy of a non-replicating adenoviral vector type 26 (Ad26) that encodes the ZIKV M-Env antigens (Ad26.ZIKV.M-Env) was evaluated in mice and non-human primates (NHP). Ad26.ZIKV.M-Env induced strong and durable cellular and humoral immune responses in preclinical models. Humoral responses were characterized by Env-binding and ZIKV neutralizing antibody responses while cellular responses were characterized by ZIKV reactive CD4+ and CD8+ T cells. Importantly, a single immunization with a very low dose of 4x107 vp of Ad26.ZIKV.M-Env protected mice from ZIKV challenge. In NHP, a single immunization with a typical human dose of 1x1011 vp of Ad26.ZIKV.M-Env also induced Env-binding and ZIKV neutralizing antibodies and Env and M specific cellular immune responses that associated with comple...Continue Reading

References

Aug 6, 2008·Emerging Infectious Diseases·Robert S LanciottiMark R Duffy
Nov 3, 2010·BJOG : an International Journal of Obstetrics and Gynaecology·K M Adams WaldorfM G Gravett
Mar 7, 2014·Human Gene Therapy·Jort VellingaMenzo Havenga
Mar 15, 2014·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·E OehlerF Ghawche
Feb 3, 2016·Annals of Internal Medicine·Lindsey R BadenUNKNOWN B003-IPCAVD004-HVTN091 Study Group
Mar 5, 2016·The New England Journal of Medicine·Patrícia BrasilKarin Nielsen-Saines
Apr 20, 2016·JAMA : the Journal of the American Medical Association·Iain D MilliganMatthew D Snape
Jun 11, 2016·The Lancet Infectious Diseases·Nitwara Wikan, Duncan R Smith
Jun 30, 2016·Nature·Rafael A LaroccaDan H Barouch
Jul 28, 2016·The New England Journal of Medicine·Annemiek A van der EijkMarion P G Koopmans
Jul 31, 2016·Virology Journal·Meghana RastogiSunit Kumar Singh
Aug 1, 2016·Cell·Haiyan ZhaoDaved H Fremont
Nov 1, 2016·Nature Medicine·Kristina M Adams WaldorfLakshmi Rajagopal
Oct 7, 2016·Science·Kimberly A DowdBarney S Graham
Oct 21, 2016·Archives of Pathology & Laboratory Medicine·Marie Louise Landry, Kirsten St George
Dec 23, 2016·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Katja SteinhagenWolfgang Schlumberger
Jan 13, 2017·Cell Host & Microbe·Annie Elong NgonoSujan Shresta
Feb 24, 2017·Immunity·Dan H BarouchNelson L Michael
Mar 24, 2017·Acta Neuropathologica·Leila ChimelliAmilcar Tanuri
May 26, 2017·PLoS Pathogens·Sydney M NguyenThaddeus G Golos
Jul 15, 2017·Cell·Justin M RichnerMichael S Diamond
Nov 17, 2017·Molecular & Cellular Proteomics : MCP·Guang SongHeng Zhu
Dec 15, 2017·Science Translational Medicine·Peter AbbinkDan H Barouch
Jan 19, 2018·Nature Communications·Alec J HirschDaniel N Streblow

❮ Previous
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Citations

Sep 14, 2019·Science Advances·Alexander T BakerAlan L Parker
Feb 27, 2020·Reviews in Medical Virology·Arianna Mahely Hurtado-MonzónRosa María Del Ángel
Jul 24, 2020·Human Vaccines & Immunotherapeutics·Stephen J Thomas, Alan Barrett
Sep 5, 2019·Pharmaceuticals·Juan-Carlos Saiz
Nov 18, 2018·Viruses·Himanshu GargAnjali Joshi
Jul 3, 2019·Tropical Medicine and Infectious Disease·Kenneth H EckelsJoseph Robert Putnak
Feb 29, 2020·Scientific Reports·Brianna L BullardEric A Weaver
Aug 12, 2020·Human Vaccines & Immunotherapeutics·Victória Alves Santos LunardelliDaniela Santoro Rosa
Nov 25, 2018·Vaccines·Khairunnisa Abdul GhaffarLaurent Renia
Apr 10, 2019·Tropical Medicine and Infectious Disease·In-Jeong KimJr-Shiuan Lin
Dec 4, 2020·Viruses·Priscila M S Castanha, Ernesto T A Marques
Jun 22, 2020·Current Opinion in Virology·Camila R Fontes-GarfiasPei-Yong Shi
Jul 31, 2020·Nature·Noe B MercadoDan H Barouch
Mar 8, 2021·Vaccine·Jerome CustersUNKNOWN Brighton Collaboration Viral Vector Vaccines Safety Working Group (V3SWG)
Jun 3, 2020·Molecular Therapy : the Journal of the American Society of Gene Therapy·Min Wen KuMaryline Bourgine
May 1, 2021·Immunological Investigations·Kirk HofmanSathy V Balu-Iyer
Jun 22, 2021·Expert Review of Vaccines·Velasco CimicaTimothy T Stedman
Dec 15, 2020·ACS Biomaterials Science & Engineering·Lampouguin Yenkoidiok-Douti, Christopher M Jewell

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Datasets Mentioned

BETA
KU497555.1

Methods Mentioned

BETA
ELISA
FACS
blood collection
fluorescence-activated cell sorting

Clinical Trials Mentioned

NCT03356561

Software Mentioned

SAS
R
FlowJo

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