Adenoviral vectors--how to use them in cancer gene therapy?

Virus Research
Dragomira Majhen, Andreja Ambriović-Ristov

Abstract

Gene therapy is most often described as a technique for introducing the foreign genetic material into cells with a correction of a dysfunctional gene as its final goal. Today, it is well known that cancer is one of the leading causes of mortality in the world. Besides classical methods for cancer treatment new strategies against cancer are needed. Although originally being designed as a treatment for monogenetic illness, soon after, gene therapy appeared as a potential new strategy in cancer therapy. One of the widely used vectors for cancer gene therapy is adenovirus. In this review we have described molecular biology of adenoviruses and basis for construction of adenoviral vectors. We have also described concepts for cancer gene therapy including their in vitro and in vivo application. Special attention is drawn toward retargeting of adenovirus as a new approach in vector design for cancer gene therapy, in order to restrict transgene expression in tumor tissue. This approach uses biophysical as well as genetic characteristics of tumor itself and its supporting tissue, allowing new "bypass" in cancer gene therapy.

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Citations

Nov 17, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ji Won ParkTae Gwan Park
Aug 4, 2009·Virus Research·Anurag SharmaSuresh K Mittal
Apr 2, 2008·Biologicals : Journal of the International Association of Biological Standardization·Chao ShenCongyi Zheng
Jan 24, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Haruna SakuraiHiroyuki Mizuguchi
Jul 23, 2008·The Journal of Pharmacy and Pharmacology·Helen O McCarthyDavid G Hirst
Aug 21, 2007·Biochemical and Biophysical Research Communications·Xinglei YaoShinsaku Nakagawa
Aug 1, 2006·Biochemical and Biophysical Research Communications·Dragomira MajhenAndreja Ambriović-Ristov
Dec 18, 2007·Biochemical and Biophysical Research Communications·Ji Won ParkTae Gwan Park
Sep 18, 2007·Orvosi hetilap·Krisztina Hagymási, Zsolt Tulassay
Apr 2, 2013·Gene·Guillaume ColletClaudine Kieda
Sep 15, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yukyung JungSeungjoo Haam
Sep 25, 2017·Biotechnology and Bioengineering·David Sharon, Amine Kamen
Mar 20, 2020·The Journal of International Medical Research·Liangquan PengDaping Wang
May 10, 2019·Frontiers in Oncology·Reena GoswamiVenkaiah Betapudi

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