Adenovirus: a blueprint for non-viral gene delivery

Current Opinion in Biotechnology
V Ann Chailertvanitkul, Colin W Pouton

Abstract

Although adenoviral vectors may not find a direct clinical role in gene therapy, an understanding of the mechanisms of DNA delivery that adenoviruses use is of vital importance to the design of next-generation non-viral gene delivery systems. Adenoviruses overcome a series of biological barriers, including endosomal escape, intracellular trafficking, capsid dissociation, and nuclear import of DNA, to deliver their genome to the host cell nucleus. The understanding of these processes at the molecular level is progressing and is set to inform the design of synthetic gene delivery systems.

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Citations

Nov 30, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jung-Hyun KimNatalay Kouprina
Oct 26, 2013·Journal of Biological Engineering·Julie ShiSuzie H Pun
Jun 9, 2012·Theoretical Biology & Medical Modelling·M Kemal IrmakAyhan Kubar
Aug 23, 2011·Journal of Vascular and Interventional Radiology : JVIR·Luke J HigginsLawrence V Hofmann
May 28, 2020·International Journal of Molecular Sciences·Ana RicobarazaRuben Hernandez-Alcoceba
Sep 11, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sara R PedersenAllan R Thomsen
Jul 21, 2021·ACS Applied Materials & Interfaces·Franziska HausigJohannes C Brendel

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