Adenovirus-derived vectors for prostate cancer gene therapy.

Human Gene Therapy
Jeroen de VrijGuy Zuber

Abstract

Prostate cancer is a leading cause of death among men in Western countries. Whereas the survival rate approaches 100% for patients with localized cancer, the results of treatment in patients with metastasized prostate cancer at diagnosis are much less successful. The patients are usually presented with a variety of treatment options, but therapeutic interventions in prostate cancer are associated with frequent adverse side effects. Gene therapy and oncolytic virus therapy may constitute new strategies. Already a wide variety of preclinical studies has demonstrated the therapeutic potential of such approaches, with oncolytic prostate-specific adenoviruses as the most prominent vector. The state of the art and future prospects of gene therapy in prostate cancer are reviewed, with a focus on adenoviral vectors. We summarize advances in adenovirus technology for prostate cancer treatment and highlight areas where further developments are necessary.

References

Mar 11, 2000·The Journal of Clinical Investigation·P T DrapkinM J Welsh
Jul 20, 2001·Journal of Virology·M K MagnussonL Lindholm
Nov 26, 2002·Immunological Reviews·Matthew J ScanlanYao-Tseng Chen
Jan 29, 2003·Journal of Virology·Wen YanYuqiao Shen
Apr 20, 2004·Molecular Therapy : the Journal of the American Society of Gene Therapy·Robert A MeulenbroekRobin J Parks
May 4, 2004·Molecular Therapy : the Journal of the American Society of Gene Therapy·Zong-Yi LiAndré Lieber
Jul 27, 2004·Nature Medicine·Paul GregorevicJeffrey S Chamberlain
Jul 29, 2004·Current Pharmaceutical Design·John RomerMichael Ploug
Aug 7, 2004·Molecular Imaging·Long P LeDavid T Curiel
May 26, 2005·The Journal of General Virology·Jort VellingaRob C Hoeben
Jun 1, 2005·Journal of Structural Biology·Sjors H W ScheresCarmen San Martín
Jun 21, 2005·Molecular Therapy : the Journal of the American Society of Gene Therapy·Florian KreppelStefan Kochanek
Nov 17, 2005·The Journal of Gene Medicine·Jort VellingaRob C Hoeben
Jan 28, 2006·Journal of Virology·T SubramanianG Chinnadurai
Dec 2, 2006·Stem Cells·Fabrício F CostaBertha Brodin
Dec 14, 2006·Molecular Therapy : the Journal of the American Society of Gene Therapy·Anthony T PowerJohn C Bell
Jan 20, 2007·Cancer Imaging : the Official Publication of the International Cancer Imaging Society
Jan 25, 2007·Molecular Therapy : the Journal of the American Society of Gene Therapy·Angelika B KritzAndrew H Baker
Apr 5, 2007·Molecular Therapy : the Journal of the American Society of Gene Therapy·Svend O FreytagJae Ho Kim
Apr 26, 2007·Molecular Therapy : the Journal of the American Society of Gene Therapy·Marxa L FigueiredoLily Wu
Jul 25, 2007·Annual Review of Cell and Developmental Biology·Neethan A LoboMichael F Clarke

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Citations

Sep 26, 2013·Ultrasound in Medicine & Biology·Anna G SoraceKenneth Hoyt
Jun 16, 2011·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Matthias DittrichGerald Brezesinski
Sep 8, 2011·Pathology·Gerald BothGeoff Symonds
May 6, 2014·Molecular Therapy : the Journal of the American Society of Gene Therapy·Weidong XuPrem Seth
Jul 21, 2017·Physical Chemistry Chemical Physics : PCCP·Stephanie TasslerGerald Brezesinski
Jan 1, 2011·Cancers·Cristina FillatLuciano Sobrevals
Aug 23, 2020·International Journal of Molecular Sciences·Natasa GasparLaura Mezzanotte

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Methods Mentioned

BETA
genetic modification
xenograft
fluorescence microscopy

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