Adenovirus infection of primary malignant lymphoid cells

Leukemia & Lymphoma
Roger K StrairDaniel J Medina

Abstract

Adenovirus infection represents a cellular stress that induces host cell pro-apoptotic responses. To overcome this barrier to productive infection, viral polypeptides modulate a variety of host cell pathways. The interface of these early viral gene products with key cellular regulatory proteins has provided considerable information concerning basic cellular mechanisms operative in cell cycle regulation, transcriptional control and apoptosis. The overlap of these mechanisms with those impacted during oncogenesis provides the opportunity to use adenoviruses and adenovirus mutants to characterize the state of key regulatory pathways in specific malignant cells. For example, adenoviruses mediate cytotoxicity after infection of chronic lymphocytic leukemia (CLL) cells, mantle cell lymphoma (MCL) cells and multiple myeloma cell lines. Specific adenovirus mutants demonstrate enhanced cytotoxicity and, in many cases, apoptosis is not the primary mechanism of cell death. Analysis of these infections with respect to both the features of the primary malignant cell and the mechanisms of adenovirus-mediated cytotoxicity holds the prospect of providing novel insights into the status of key regulatory pathways in individual patient malignant ...Continue Reading

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Citations

Nov 3, 2011·Bone Marrow Research·Chandini M Thirukkumaran, Don G Morris
Mar 21, 2008·Expert Opinion on Biological Therapy·Amaalia E Stief, J Andrea McCart
Oct 15, 2003·Clinical Lymphoma·Tommy AlainAnna E Kossakowska
Nov 3, 2005·Experimental Hematology·Daniel J MedinaRoger K Strair
Mar 14, 2007·International Journal of Cancer. Journal International Du Cancer·Claudia SchöllkopfHenrik Hjalgrim

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