PMID: 9525681Apr 3, 1998Paper

Adenovirus internalization and infection require dynamin

Journal of Virology
K WangG Nemerow

Abstract

The cell receptors that facilitate adenovirus internalization into cells have been identified; however, the infectious pathway of virus entry has not been established. Adenovirus entry and infection were examined in HeLa cells lacking or overexpressing mutant dynamin, a protein that specifically regulates clathrin-mediated endocytosis. Expression of mutant dynamin significantly reduced adenovirus internalization and gene delivery, indicating a functional requirement for this molecule. These findings are consistent with virus entry via the clathrin-coated pit pathway.

References

Jun 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·M Gossen, H Bujard
Nov 1, 1991·Journal of Virology·M J VargaE Everitt
Sep 1, 1988·Journal of Cellular Physiology·D N McKinley, H S Wiley
May 1, 1983·The Journal of General Virology·S Patterson, W C Russell
Aug 1, 1995·Current Opinion in Cell Biology·C Lamaze, S L Schmid
Oct 1, 1994·The Journal of General Virology·L Pérez, L Carrasco
Nov 1, 1994·The Journal of Cell Biology·H DamkeS L Schmid
Mar 1, 1994·The Journal of Cell Biology·L J HewlettC Watts
Apr 1, 1997·Proceedings of the National Academy of Sciences of the United States of America·R P TomkoL Philipson
Jul 22, 1997·Proceedings of the National Academy of Sciences of the United States of America·S HuangG Nemerow
Jul 1, 1997·Physiological Reviews·S MukherjeeF R Maxfield

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Citations

May 9, 2000·The Journal of Biological Chemistry·E LiG R Nemerow
Jun 14, 2003·Human Gene Therapy·Theodore A G SmithSusan C Stevenson
Jun 11, 2003·The Journal of Gene Medicine·Oliver Meier, Urs F Greber
Aug 6, 2003·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·John Nemunaitis
Dec 4, 2003·Journal of Virology·Christopher J BaileyPhilip L Leopold
Feb 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Brenna CareyBruce C Trapnell
Jul 14, 2012·The Journal of General Virology·Zhimin WangYehia Daaka
Jun 21, 2002·The Journal of General Virology·Sara B Sieczkarski, Gary R Whittaker
Feb 13, 2001·Journal of Virology·P Joki-KorpelaT Hyypiä
Jan 29, 2005·Cancer Gene Therapy·Birgit Ø EngesaeterGunhild M Maelandsmo
Apr 14, 2006·Cancer Immunology, Immunotherapy : CII·Susan J HedleyImre Kovesdi
Jun 16, 2005·Journal of Virology·Vivian O'DonnellBarry Baxt
Dec 2, 2004·Expert Opinion on Biological Therapy·Graeme J DoughertyShona T Dougherty
Apr 9, 2019·Open Biology·Justin W Flatt, Sarah J Butcher
Aug 23, 2000·Journal of Virology·J M Gilbert, T L Benjamin
Feb 24, 2001·Traffic·M Marsh, A Pelchen-Matthews
Feb 23, 2000·Journal of Virology·J S BartlettR J Samulski
Jul 2, 2003·Gene Therapy·H BüningM Hallek
Oct 20, 2000·The Journal of General Virology·W C Russell
Mar 3, 2004·Journal of Virology·Nicola ImelliUrs F Greber
Oct 14, 2000·Annual Review of Cell and Developmental Biology·J E Hinshaw
Aug 21, 2002·Journal of Virology·Amanda D StuartT D K Brown
Mar 1, 2003·Journal of Virology·Wei Zhang, Michael J Imperiale
Jan 29, 2003·Journal of Virology·Katherine J D Ashbourne ExcoffonJoseph Zabner

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