Adenovirus-mediated interleukin-35 gene transfer suppresses allergic airway inflammation in a murine model of asthma

Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]
Yan LiMingcai Li

Abstract

Asthma is thought to result from the generation of T helper type 2 (Th2) responses, leading to bronchial inflammation. Interleukin (IL)-35 is a recently described member of IL-12 cytokine family that plays a critical role in influencing Th cell differentiation and inflammatory processes. The aim of this study was to examine the effect of adenovirus expressing IL-35 (AdIL-35) on allergic airway hyperresponsiveness (AHR) and inflammation in a mouse model of asthma. BALB/c mice were subjected to an established model of allergic airway disease. AdIL-35 was administered intranasally and the effect of IL-35 on Th2 responses, pulmonary inflammation, goblet cell metaplasia, and AHR were assessed. Transfer of AdIL-35 significantly reduced the severity of AHR and numbers of inflammatory cells and levels of IL-4, IL-5, IL-13, and IL-17 in bronchoalveolar lavage fluid, compared with administration of a control virus. Moreover, AdIL-35 elevated the numbers of CD4+CD25+Foxp3+ regulatory T cells in the lungs. Histological analysis showed that AdIL-35 inhibited allergic lung tissue inflammation and mucus hypersecretion. These results demonstrate that adenovirus-mediated delivery of interleukin-35 gene can mitigate allergic airway inflammation ...Continue Reading

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Citations

Oct 4, 2016·Inflammation·Shi-Yang GuanHai-Feng Pan
Oct 7, 2016·Allergology International : Official Journal of the Japanese Society of Allergology·Motohiko SuzukiShingo Murakami
Mar 16, 2019·Mucosal Immunology·William J Branchett, Clare M Lloyd
Apr 17, 2020·Respiratory Research·Wei LiPeng Gao
Apr 9, 2020·Experimental and Therapeutic Medicine·Lei QianGuangliang Liu
Feb 28, 2020·Experimental and Therapeutic Medicine·Wei PanXingyu Song
Sep 16, 2020·Journal of Bioenergetics and Biomembranes·Jie ZhangFeng Liu
May 30, 2017·Mediators of Inflammation·Peng GaoJie Zhang
Dec 29, 2020·The Journal of International Medical Research·Jing-Jing Zhu, Ning-Ning Shan
Aug 14, 2021·Asia Pacific Allergy·Hideaki KouzakiTakeshi Shimizu

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