Adenovirus membrane penetration: Tickling the tail of a sleeping dragon

Virology
Christopher M Wiethoff, G R Nemerow

Abstract

As is the case for nearly every viral pathogen, non-enveloped viruses (NEV) must maintain their integrity under potentially harsh environmental conditions while retaining the ability to undergo rapid disassembly at the right time and right place inside host cells. NEVs generally exist in this metastable state until they encounter key cellular stimuli such as membrane receptors, decreased intracellular pH, digestion by cellular proteases, or a combination of these factors. These stimuli trigger conformational changes in the viral capsid that exposes a sequestered membrane-perturbing protein. This protein subsequently modifies the cell membrane in such a way as to allow passage of the virion and accompanying nucleic acid payload into the cell cytoplasm. Different NEVs employ variations of this general pathway for cell entry (Moyer and Nemerow, 2011, Curr. Opin. Virol., 1, 44-49), however this review will focus on significant new knowledge obtained on cell entry by human adenovirus (HAdV).

References

Oct 1, 1994·The Journal of Cell Biology·T J WickhamG R Nemerow
Oct 1, 1994·The Journal of General Virology·L Pérez, L Carrasco
Dec 10, 1999·Journal of Virology·N ArnbergG Wadell
Mar 10, 2001·Biopolymers·R M Epand, R F Epand
Jun 14, 2003·Human Gene Therapy·Theodore A G SmithSusan C Stevenson
Oct 21, 2003·Nature Medicine·Anuj GaggarAndré Lieber
Jun 29, 2004·Journal of Virology·Wim P BurmeisterNiklas Arnberg
Jan 5, 2005·Molecular Cell·Chloe ZubietaStephen Cusack
Feb 1, 2005·Journal of Virology·Christopher M WiethoffGlen R Nemerow
Apr 30, 2005·The EMBO Journal·Céline M S FabryGuy Schoehn
Nov 15, 2005·Proceedings of the National Academy of Sciences of the United States of America·Glen A FarrPeter Tattersall
Jan 16, 2007·Nature Structural & Molecular Biology·B David PerssonThilo Stehle
Feb 13, 2008·Cell·Simon N WaddingtonAndrew H Baker
Mar 8, 2008·The EMBO Journal·Beat AmstutzUrs F Greber
Apr 9, 2008·Proceedings of the National Academy of Sciences of the United States of America·O KalyuzhniyD M Shayakhmetov
Jun 6, 2008·Journal of Virology·Lars PacheGlen R Nemerow
May 23, 2009·PLoS Pathogens·Sara SalinasEric J Kremer
Dec 3, 2009·Cellular Microbiology·Irit PazPhilippe Sansonetti

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Citations

May 28, 2016·Current Opinion in Microbiology·Nihal Altan-Bonnet
Aug 20, 2016·Angewandte Chemie·Yilong ChengSuzie H Pun
Nov 14, 2016·Trends in Cell Biology·Nihal Altan-Bonnet
Sep 17, 2016·PLoS Pathogens·Karsten EichholzEric J Kremer
Nov 13, 2015·Viruses·Pei-Hsin ChengHeshan Sam Zhou
Dec 16, 2017·Journal of Biological Physics·Mariska G M van RosmalenWouter H Roos
Apr 14, 2017·Journal of Virology·Jingwei Xu, Ye Xiang
Sep 6, 2019·Journal of Virology·Kimi Azad, Manidipa Banerjee
Mar 17, 2018·Virus Genes·Ana Carla Peixoto GuissoniDivina das Dores de Paula Cardoso
Apr 9, 2019·Open Biology·Justin W Flatt, Sarah J Butcher
Feb 10, 2021·Signal Transduction and Targeted Therapy·Jote T BulchaGuangping Gao
Apr 2, 2021·Clinical Microbiology Reviews·Nicola ClementiNicasio Mancini

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