PMID: 32669173Jul 17, 2020Paper

Adenovirus pneumonia with hemophagocytic lymphohistiocytosis in children: a clinical analysis of 7 children

Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
Jie ChenXing-Xing Zhang

Abstract

To study the clinical features of children with adenovirus pneumonia and hemophagocytic lymphohistiocytosis (HLH). A retrospective analysis was performed on the mediacal data of 7 children with adenovirus pneumonia and HLH from March to September, 2019. The age of these children ranged from 11 months to 5 years, and among these children, 5 were aged <2 years and 5 were boys. None of these children had underlying diseases. All children were hospitalized due to persistent high fever and cough, and the peak temperature of fever was 39°C to 41°C. With disease progression, 7 children developed hepatomegaly and 6 developed splenomegaly. Routine blood test results showed reductions in two or three lineages of blood cells, with increases in serum ferritin (SF), C-reactive protein (CRP), procalcitonin (PCT), and lactate dehydrogenase (LDH). Phagocytosis of blood cells was observed in 6 children. Radiological examination of lungs showed pneumonia changes. All 7 children were diagnosed with human adenovirus type 7 infection based on pathogenic metagenome detection. No abnormality was found by HLH gene detection and the children were diagnosed with secondary HLH. All children received intravenous immunoglobulin. Among these children, 4 rec...Continue Reading

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